Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4DWJ

Crystal structure of Thymidylate Kinase from Staphylococcus aureus in complex with Thymidine Monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004798	molecular_function	dTMP kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006227	biological_process	dUDP biosynthetic process
A	0006233	biological_process	dTDP biosynthetic process
A	0006235	biological_process	dTTP biosynthetic process
A	0006520	biological_process	amino acid metabolic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016597	molecular_function	amino acid binding
A	0016740	molecular_function	transferase activity
A	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
B	0000166	molecular_function	nucleotide binding
B	0004798	molecular_function	dTMP kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006227	biological_process	dUDP biosynthetic process
B	0006233	biological_process	dTDP biosynthetic process
B	0006235	biological_process	dTTP biosynthetic process
B	0006520	biological_process	amino acid metabolic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016597	molecular_function	amino acid binding
B	0016740	molecular_function	transferase activity
B	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
C	0000166	molecular_function	nucleotide binding
C	0004798	molecular_function	dTMP kinase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006227	biological_process	dUDP biosynthetic process
C	0006233	biological_process	dTDP biosynthetic process
C	0006235	biological_process	dTTP biosynthetic process
C	0006520	biological_process	amino acid metabolic process
C	0009165	biological_process	nucleotide biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016597	molecular_function	amino acid binding
C	0016740	molecular_function	transferase activity
C	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
D	0000166	molecular_function	nucleotide binding
D	0004798	molecular_function	dTMP kinase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006227	biological_process	dUDP biosynthetic process
D	0006233	biological_process	dTDP biosynthetic process
D	0006235	biological_process	dTTP biosynthetic process
D	0006520	biological_process	amino acid metabolic process
D	0009165	biological_process	nucleotide biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016597	molecular_function	amino acid binding
D	0016740	molecular_function	transferase activity
D	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
E	0000166	molecular_function	nucleotide binding
E	0004798	molecular_function	dTMP kinase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006227	biological_process	dUDP biosynthetic process
E	0006233	biological_process	dTDP biosynthetic process
E	0006235	biological_process	dTTP biosynthetic process
E	0006520	biological_process	amino acid metabolic process
E	0009165	biological_process	nucleotide biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016597	molecular_function	amino acid binding
E	0016740	molecular_function	transferase activity
E	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
F	0000166	molecular_function	nucleotide binding
F	0004798	molecular_function	dTMP kinase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006227	biological_process	dUDP biosynthetic process
F	0006233	biological_process	dTDP biosynthetic process
F	0006235	biological_process	dTTP biosynthetic process
F	0006520	biological_process	amino acid metabolic process
F	0009165	biological_process	nucleotide biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016597	molecular_function	amino acid binding
F	0016740	molecular_function	transferase activity
F	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
G	0000166	molecular_function	nucleotide binding
G	0004798	molecular_function	dTMP kinase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006227	biological_process	dUDP biosynthetic process
G	0006233	biological_process	dTDP biosynthetic process
G	0006235	biological_process	dTTP biosynthetic process
G	0006520	biological_process	amino acid metabolic process
G	0009165	biological_process	nucleotide biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016597	molecular_function	amino acid binding
G	0016740	molecular_function	transferase activity
G	0016743	molecular_function	carboxyl- or carbamoyltransferase activity
H	0000166	molecular_function	nucleotide binding
H	0004798	molecular_function	dTMP kinase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006227	biological_process	dUDP biosynthetic process
H	0006233	biological_process	dTDP biosynthetic process
H	0006235	biological_process	dTTP biosynthetic process
H	0006520	biological_process	amino acid metabolic process
H	0009165	biological_process	nucleotide biosynthetic process
H	0016301	molecular_function	kinase activity
H	0016597	molecular_function	amino acid binding
H	0016740	molecular_function	transferase activity
H	0016743	molecular_function	carboxyl- or carbamoyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TMP A 301

Chain	Residue
A	ARG36
A	ARG48
A	PHE66
A	ARG70
A	ARG92
A	SER97
A	TYR100
A	GLN101

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE TMP B 301

Chain	Residue
B	THR16
B	ARG36
B	PHE66
B	ARG70
B	ASP91
B	ARG92
B	SER96
B	SER97
B	GLN101
B	LYS15

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TMP C 301

Chain	Residue
C	LYS15
C	THR16
C	PHE66
C	ARG70
C	ARG92
C	SER97
C	GLN101

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE TMP D 301

Chain	Residue
D	LYS15
D	ARG36
D	PHE66
D	ARG70
D	ASP91
D	ARG92
D	SER97
D	TYR100
D	GLN101

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE TMP F 301

Chain	Residue
F	GLU37
F	PHE66
F	ARG70
F	SER97
F	GLN101

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TMP G 301

Chain	Residue
G	LYS15
G	ARG36
G	PHE66
G	ARG70
G	ARG92
G	SER97
G	TYR100
G	GLN101

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE TMP H 301

Chain	Residue
H	LYS15
H	ARG36
H	PHE66
H	ARG70
H	ARG92
H	SER97
H	TYR100
H	GLN101

Functional Information from PROSITE/UniProt

site_id	PS01331
Number of Residues	13
Details	THYMIDYLATE_KINASE Thymidylate kinase signature. LCDRYidSSlAYQ

Chain	Residue	Details
A	LEU89-GLN101

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00165","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)