4DUK

Carboxypeptidase T with L-BENZYLSUCCINIC ACID

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004181	molecular_function	metallocarboxypeptidase activity
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 401

Chain	Residue
A	HIS69
A	GLU72
A	HIS204
A	BZS405

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 402

Chain	Residue
A	HOH748
A	SER7
A	TYR9
A	GLU14
A	HOH507
A	HOH569

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 403

Chain	Residue
A	SER50
A	ASP51
A	GLU57
A	GLU59
A	HOH595
A	HOH685

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 404

Chain	Residue
A	TYR5
A	ASP291
A	GLU292
A	HOH577
A	HOH673

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE BZS A 405

Chain	Residue
A	HIS69
A	GLU72
A	ARG129
A	ASN146
A	ARG147
A	HIS204
A	THR205
A	ALA251
A	LEU254
A	TYR255
A	THR257
A	ASP260
A	GLU277
A	ZN401

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 406

Chain	Residue
A	VAL16
A	ASN20
A	THR21
A	ASN25
A	LYS32
A	TRP45
A	HOH549
A	HOH728

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 407

Chain	Residue
A	HIS10
A	LYS18
A	ASP84
A	GOL414

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 408

Chain	Residue
A	TYR12
A	ASN13
A	ARG42
A	GLU117
A	GOL415
A	HOH687

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 409

Chain	Residue
A	PHE33
A	ASP184
A	PHE185
A	GOL410
A	HOH556

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 410

Chain	Residue
A	LYS31
A	TYR106
A	GOL409
A	HOH571
A	HOH798
A	HOH799

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 411

Chain	Residue
A	ARG71
A	LYS152
A	GLU166
A	TYR216
A	GOL412
A	HOH738
A	HOH758

---

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 412

Chain	Residue
A	ARG71
A	ARG129
A	GLU166
A	TYR255
A	GOL411
A	GOL417
A	HOH625
A	HOH750

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 413

Chain	Residue
A	THR226
A	GLN227
A	HOH534
A	HOH642
A	HOH773

---

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 414

Chain	Residue
A	HIS10
A	GLU77
A	LEU80
A	TYR81
A	ASP84
A	GOL407
A	HOH579
A	HOH716

---

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 415

Chain	Residue
A	ASP1
A	ASN11
A	GLU117
A	GOL408
A	HOH559
A	HOH609
A	HOH699

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 416

Chain	Residue
A	ASN25
A	ASN28
A	LYS31
A	LYS32
A	HOH617

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 417

Chain	Residue
A	TYR206
A	SER207
A	GOL412
A	HOH646

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 418

Chain	Residue
A	TRP128
A	ARG132
A	HOH519
A	HOH683
A	HOH689

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 419

Chain	Residue
A	GLY193
A	GLN195
A	HIS269
A	HOH705
A	HOH710

---

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 420

Chain	Residue
A	GLY157
A	GLY157
A	GLY158
A	SER159
A	THR167
A	HOH542
A	HOH567
A	HOH636
A	HOH776

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 421

Chain	Residue
A	LEU209
A	GLN249
A	ASP253
A	LEU254
A	HOH722

---

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 422

Chain	Residue
A	HOH576
A	HOH583
A	HOH597
A	HOH638
A	HOH775

---

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL A 423

Chain	Residue
A	GLY137
A	SER138
A	SER139
A	TYR140
A	ARG171
A	SER172
A	HOH565
A	HOH586

---

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 424

Chain	Residue
A	GLU292
A	ARG296
A	SER299
A	LYS302
A	GLU303
A	HOH530
A	HOH783

---

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 425

Chain	Residue
A	GLY8
A	ASP291
A	HOH747

---

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 426

Chain	Residue
A	ASN58
A	PRO60
A	ASN102
A	ASP313
A	HOH784

---

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 427

Chain	Residue
A	ASP56
A	GLU57
A	GLU59
A	GLU61
A	GLU104
A	HOH678
A	HOH679

---

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 428

Chain	Residue
A	ARG183
A	ASN187
A	TRP264
A	GLN268
A	GOL429
A	HOH711

---

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 429

Chain	Residue
A	GLY150
A	PHE174
A	TRP264
A	SO4428
A	HOH603
A	HOH702

---

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 430

Chain	Residue
A	GLU310
A	LYS311
A	HOH774
A	HOH800

---

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 431

Chain	Residue
A	ASN89
A	ASP93
A	LYS302
A	GOL432
A	HOH752

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 432

Chain	Residue
A	TYR81
A	SER299
A	GOL431
A	HOH795

---

Functional Information from PROSITE/UniProt

site_id	PS00132
Number of Residues	23
Details	CARBOXYPEPT_ZN_1 Zinc carboxypeptidases, zinc-binding region 1 signature. PeVlYtaLhHArEhLTVemalyT

Chain	Residue	Details
A	PRO60-THR82

---

site_id	PS00133
Number of Residues	11
Details	CARBOXYPEPT_ZN_2 Zinc carboxypeptidases, zinc-binding region 2 signature. HTYSELIlYPY

Chain	Residue	Details
A	HIS204-TYR214

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	304
Details	Domain: {"description":"Peptidase M14","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1521526","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01379","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"1521526","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---