4DPU
Crystal structure of Staphylococcus epidermidis S192A mevalonate diphosphate decarboxylase complexed with inhibitor 6-FMVAPP and ATPgS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0004163 | molecular_function | diphosphomevalonate decarboxylase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE FM0 A 401 |
| Chain | Residue |
| A | ALA14 |
| A | MET196 |
| A | ASP283 |
| A | ALA284 |
| A | AGS402 |
| A | HOH579 |
| A | HOH693 |
| A | TYR18 |
| A | TRP19 |
| A | LYS21 |
| A | SER139 |
| A | GLY140 |
| A | SER141 |
| A | ARG144 |
| A | ARG193 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE AGS A 402 |
| Chain | Residue |
| A | THR43 |
| A | LEU60 |
| A | GLU69 |
| A | LYS72 |
| A | SER94 |
| A | ASN96 |
| A | ALA105 |
| A | SER106 |
| A | SER107 |
| A | ALA108 |
| A | ALA110 |
| A | SER141 |
| A | FM0401 |
| A | HOH590 |
| A | HOH662 |
| A | HOH678 |
| A | HOH693 |
| A | HOH700 |
| A | HOH715 |
| A | HOH733 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE FM0 B 401 |
| Chain | Residue |
| B | ALA14 |
| B | TYR18 |
| B | TRP19 |
| B | LYS21 |
| B | SER107 |
| B | SER139 |
| B | GLY140 |
| B | SER141 |
| B | ARG144 |
| B | ALA192 |
| B | ARG193 |
| B | MET196 |
| B | ASP283 |
| B | ALA284 |
| B | AGS402 |
| B | HOH566 |
| B | HOH615 |
| B | HOH673 |
| B | HOH724 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AGS B 402 |
| Chain | Residue |
| B | THR43 |
| B | LEU60 |
| B | GLU69 |
| B | SER94 |
| B | ASN96 |
| B | ALA105 |
| B | SER106 |
| B | SER107 |
| B | ALA110 |
| B | SER141 |
| B | SER191 |
| B | ALA192 |
| B | FM0401 |
| B | HOH570 |
| B | HOH626 |
| B | HOH673 |
| B | HOH754 |
