4DMK

Crystal structure of the CFTR inhibitory factor Cif with the Y239F mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004301	molecular_function	epoxide hydrolase activity
A	0005576	cellular_component	extracellular region
A	0043657	cellular_component	host cell
B	0004301	molecular_function	epoxide hydrolase activity
B	0005576	cellular_component	extracellular region
B	0043657	cellular_component	host cell
C	0004301	molecular_function	epoxide hydrolase activity
C	0005576	cellular_component	extracellular region
C	0043657	cellular_component	host cell
D	0004301	molecular_function	epoxide hydrolase activity
D	0005576	cellular_component	extracellular region
D	0043657	cellular_component	host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	ASP129
A	HOH653
A	HOH682
A	GLU153
A	ALA154
A	PRO155
A	VAL175
A	PHE178
A	HIS207
A	HIS297
A	HOH529

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL B 401

Chain	Residue
B	ASP129
B	GLU153
B	ALA154
B	HIS177
B	PHE178
B	PHE239
B	HIS297
B	HOH608
B	HOH792
B	HOH795

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL C 401

Chain	Residue
C	ASP129
C	GLU153
C	ALA154
C	PRO155
C	VAL175
C	HIS207
C	HIS297
C	HOH531
C	HOH646
C	HOH677

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 401

Chain	Residue
D	ASP129
D	GLU153
D	PRO155
D	HIS207
D	HIS297
D	HOH567
D	HOH664
D	HOH783

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	440
Details	Domain: {"description":"AB hydrolase-1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile; hydroxyalkyl-enzyme intermediate","evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"20118260","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21933119","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26136396","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26752215","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27980032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28392259","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4DNF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EUS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JYC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---