4DEC
Crystal structure of glucosyl-3-phosphoglycerate synthase from Mycobacterium tuberculosis in complex with Mn2+, uridine-diphosphate (UDP) and phosphoglyceric acid (PGA)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0006011 | biological_process | UDP-glucose metabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016758 | molecular_function | hexosyltransferase activity |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE UDP A 401 |
| Chain | Residue |
| A | PRO50 |
| A | ASP136 |
| A | TYR229 |
| A | ARG259 |
| A | ARG261 |
| A | MN402 |
| A | HOH548 |
| A | HOH693 |
| A | HOH697 |
| A | HOH713 |
| A | ALA51 |
| A | LEU52 |
| A | GLU54 |
| A | SER81 |
| A | GLY113 |
| A | LYS114 |
| A | ASP134 |
| A | SER135 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 402 |
| Chain | Residue |
| A | ASP136 |
| A | HIS258 |
| A | UDP401 |
| A | HOH501 |
| A | HOH713 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE 3PG A 403 |
| Chain | Residue |
| A | GLY184 |
| A | ARG185 |
| A | VAL186 |
| A | THR187 |
| A | ASN260 |
| A | HOH713 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 404 |
| Chain | Residue |
| A | GLN159 |
| A | GLU218 |
| A | LEU219 |
| A | ARG242 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 405 |
| Chain | Residue |
| A | ARG97 |
| A | VAL98 |
| A | HOH674 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 A 406 |
| Chain | Residue |
| A | THR25 |
| A | TRP26 |
| A | HIS27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U, ECO:0007744|PDB:4Y7F, ECO:0007744|PDB:4Y7G, ECO:0007744|PDB:4Y9X |
| Chain | Residue | Details |
| A | PRO50 | |
| A | SER81 | |
| A | LYS114 | |
| A | ASP134 | |
| A | ASP136 | |
| A | TYR229 | |
| A | HIS258 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0000269|PubMed:28625787, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U, ECO:0007744|PDB:4Y9X, ECO:0007744|PDB:5JQX |
| Chain | Residue | Details |
| A | GLY184 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:28625787, ECO:0007744|PDB:5JT0 |
| Chain | Residue | Details |
| A | ARG256 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:26136334, ECO:0007744|PDB:4Y6N, ECO:0007744|PDB:4Y6U |
| Chain | Residue | Details |
| A | ASN260 |
