4DCB

Y. pestis Plasminogen Activator Pla in Complex with Human Plasminogen Activation Loop Peptide ALP11

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0009279	cellular_component	cell outer membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 401

Chain	Residue
A	SER63
A	PHE64
A	LEU75
A	TRP119
A	GLN122

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 402

Chain	Residue
A	HOH546
A	PRO175
A	ASN186
A	ASP187
A	TYR233

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 403

Chain	Residue
A	ALA18
A	SER19
A	THR20
A	VAL116
A	ALA286
A	GLY287
A	C8E407

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 404

Chain	Residue
A	ALA69
A	GLY71
A	TRP72
A	TYR126
A	TYR183
A	MPD406
A	HOH553

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MPD A 405

Chain	Residue
A	PRO175
A	TYR176
A	ILE177
A	PHE196
A	SER197
A	ASP198
A	THR236
A	ALA239
A	LEU288
A	TYR290

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD A 406

Chain	Residue
A	ALA17
A	ALA18
A	MRD404

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE C8E A 407

Chain	Residue
A	LEU67
A	ASN68
A	LEU114
A	ASN115
A	VAL116
A	LEU190
A	VAL241
A	ALA286
A	MRD403

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 408

Chain	Residue
A	TYR126
A	ALA180
A	GLY181
A	TYR183
A	PHE194

---

Functional Information from PROSITE/UniProt

site_id	PS00834
Number of Residues	10
Details	OMPTIN_1 Aspartyl proteases, omptin family signature 1. WTDhSsHPaT

Chain	Residue	Details
A	TRP95-THR104

---

site_id	PS00835
Number of Residues	17
Details	OMPTIN_2 Aspartyl proteases, omptin family signature 2. AGYQETRFSWTAtGGSY

Chain	Residue	Details
A	ALA132-TYR148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by plasminogen activator

Chain	Residue	Details
F	ARG561

---

site_id	SWS_FT_FI2
Number of Residues	164
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	GLY21-VAL50
A	LEU75-GLU111
A	GLN135-MET174
A	SER197-TYR224
A	SER248-ASN281

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	TRANSMEM: Beta stranded; Name=2 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	ALA51-ASP60

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	TOPO_DOM: Periplasmic => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	PRO61-PHE64
A	LEU121-ASN125
A	ILE185-ASP187
A	THR236-ASN238

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	TRANSMEM: Beta stranded; Name=3 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	LEU65-SER74

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	TRANSMEM: Beta stranded; Name=4 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	TYR112-LEU120

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	TRANSMEM: Beta stranded; Name=5 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	TYR126-TYR134

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	TRANSMEM: Beta stranded; Name=6 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	PRO175-ARG184

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	TRANSMEM: Beta stranded; Name=7 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	PHE188-PHE196

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	TRANSMEM: Beta stranded; Name=8 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	TYR225-VAL235

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	TRANSMEM: Beta stranded; Name=9 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	ALA239-TYR247

---

site_id	SWS_FT_FI12
Number of Residues	10
Details	TRANSMEM: Beta stranded; Name=10 => ECO:0000269|PubMed:20637417

Chain	Residue	Details
A	TYR282-PHE292

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:17635705, ECO:0000305|PubMed:20637417

Chain	Residue	Details
A	ASN84

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	ACT_SITE: ACT_SITE => ECO:0000305|PubMed:20637417

Chain	Residue	Details
A	ASP86
A	ASP206
A	HIS208

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 425

Chain

Residue

Details

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