4DCB

Y. pestis Plasminogen Activator Pla in Complex with Human Plasminogen Activation Loop Peptide ALP11

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004175	molecular_function	endopeptidase activity
A	0004190	molecular_function	aspartic-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008233	molecular_function	peptidase activity
A	0009279	cellular_component	cell outer membrane
A	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 401

Chain	Residue
A	SER63
A	PHE64
A	LEU75
A	TRP119
A	GLN122

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MRD A 402

Chain	Residue
A	HOH546
A	PRO175
A	ASN186
A	ASP187
A	TYR233

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 403

Chain	Residue
A	ALA18
A	SER19
A	THR20
A	VAL116
A	ALA286
A	GLY287
A	C8E407

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 404

Chain	Residue
A	ALA69
A	GLY71
A	TRP72
A	TYR126
A	TYR183
A	MPD406
A	HOH553

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MPD A 405

Chain	Residue
A	PRO175
A	TYR176
A	ILE177
A	PHE196
A	SER197
A	ASP198
A	THR236
A	ALA239
A	LEU288
A	TYR290

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD A 406

Chain	Residue
A	ALA17
A	ALA18
A	MRD404

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE C8E A 407

Chain	Residue
A	LEU67
A	ASN68
A	LEU114
A	ASN115
A	VAL116
A	LEU190
A	VAL241
A	ALA286
A	MRD403

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PO4 A 408

Chain	Residue
A	TYR126
A	ALA180
A	GLY181
A	TYR183
A	PHE194

---

Functional Information from PROSITE/UniProt

site_id	PS00834
Number of Residues	10
Details	OMPTIN_1 Aspartyl proteases, omptin family signature 1. WTDhSsHPaT

Chain	Residue	Details
A	TRP95-THR104

---

site_id	PS00835
Number of Residues	17
Details	OMPTIN_2 Aspartyl proteases, omptin family signature 2. AGYQETRFSWTAtGGSY

Chain	Residue	Details
A	ALA132-TYR148

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Transmembrane: {"description":"Beta stranded; Name=1","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	131
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	9
Details	Transmembrane: {"description":"Beta stranded; Name=2","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	11
Details	Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	9
Details	Transmembrane: {"description":"Beta stranded; Name=3","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Transmembrane: {"description":"Beta stranded; Name=4","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	8
Details	Transmembrane: {"description":"Beta stranded; Name=5","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	9
Details	Transmembrane: {"description":"Beta stranded; Name=6","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	8
Details	Transmembrane: {"description":"Beta stranded; Name=7","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Transmembrane: {"description":"Beta stranded; Name=8","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	8
Details	Transmembrane: {"description":"Beta stranded; Name=9","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	10
Details	Transmembrane: {"description":"Beta stranded; Name=10","evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PubMed","id":"17635705","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"20637417","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	1
Details	Site: {"description":"Cleavage; by plasminogen activator"}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 425

Chain

Residue

Details

---