4DA4

Structure of mouse DNMT1 (731-1602) bound to hemimethylated CpG DNA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003682	molecular_function	chromatin binding
A	0008168	molecular_function	methyltransferase activity
B	0003682	molecular_function	chromatin binding
B	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH A 1701

Chain	Residue
A	PHE1148
A	ASP1193
A	CYS1194
A	GLY1226
A	LYS1247
A	LEU1250
A	ALA1581
A	VAL1582
A	HOH1805
A	HOH1808
A	HOH1834
A	SER1149
A	HOH1900
D	C4918
A	GLY1150
A	GLY1152
A	GLY1153
A	LEU1154
A	GLU1171
A	MET1172
A	TRP1173

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1702

Chain	Residue
A	CYS1479
A	CYS1481
A	CYS1487
A	HIS1504

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1703

Chain	Residue
A	HIS796
A	CYS823
A	CYS897
A	CYS900

---

site_id	AC4
Number of Residues	23
Details	BINDING SITE FOR RESIDUE SAH B 1701

Chain	Residue
B	PHE1148
B	SER1149
B	GLY1150
B	GLY1152
B	GLY1153
B	LEU1154
B	GLU1171
B	MET1172
B	TRP1173
B	ASP1193
B	CYS1194
B	GLY1226
B	LYS1247
B	LEU1250
B	ALA1581
B	VAL1582
B	HOH1875
B	HOH1903
B	HOH1940
B	HOH1963
B	HOH2009
B	HOH2153
F	C4918

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1702

Chain	Residue
B	CYS1479
B	CYS1481
B	CYS1487
B	HIS1504

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1703

Chain	Residue
B	HIS796
B	CYS823
B	CYS897
B	CYS900

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CIT B 1704

Chain	Residue
A	ARG1566
A	PHE1568
A	GLY1569
A	ARG1574
A	HOH1910
A	HOH2182
B	ARG1566
B	PHE1567
B	PHE1568
B	GLY1569
B	ARG1574
B	HOH1840
B	HOH2039

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1221-SER1233

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1576-ILE1594

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	254
Details	Domain: {"description":"BAH 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00370","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PubMed","id":"17576694","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DA4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PT9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DA4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21163962","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PT9","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P26358","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	14
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P26358","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---