4D6Q
crystal structure of human JMJD2D in complex with 2,4-PDCA
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1341 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 1342 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | PD21343 |
| A | HOH2287 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE PD2 A 1343 |
| Chain | Residue |
| A | TYR136 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | LYS210 |
| A | LYS245 |
| A | HIS280 |
| A | NI1342 |
| A | EDO1348 |
| A | HOH2234 |
| A | HOH2286 |
| A | HOH2287 |
| A | HOH2293 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1344 |
| Chain | Residue |
| A | LYS150 |
| A | GLN151 |
| A | TRP152 |
| A | ASN153 |
| A | HIS156 |
| A | HOH2054 |
| A | HOH2055 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1345 |
| Chain | Residue |
| A | PRO251 |
| A | THR252 |
| A | LYS255 |
| A | ARG263 |
| A | HOH2405 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1346 |
| Chain | Residue |
| A | PHE118 |
| A | GLU122 |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| A | HOH2406 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1347 |
| Chain | Residue |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1348 |
| Chain | Residue |
| A | TYR179 |
| A | TYR181 |
| A | GLU194 |
| A | ALA292 |
| A | PD21343 |
| A | HOH2287 |
| A | HOH2293 |
| A | HOH2370 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1349 |
| Chain | Residue |
| A | ARG60 |
| A | GLU61 |
| A | THR62 |
| A | HOH2120 |
| A | HOH2123 |
| A | HOH2264 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
