Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4D4P

Crystal Structure of the Kti11 Kti13 heterodimer Spacegroup P65

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002098	biological_process	tRNA wobble uridine modification
A	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
A	0003674	molecular_function	molecular_function
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008033	biological_process	tRNA processing
A	0008198	molecular_function	ferrous iron binding
A	0008270	molecular_function	zinc ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0016567	biological_process	protein ubiquitination
A	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
A	0017183	biological_process	protein histidyl modification to diphthamide
A	0034986	molecular_function	iron chaperone activity
A	0046872	molecular_function	metal ion binding
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity
B	0002098	biological_process	tRNA wobble uridine modification
B	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
B	0003674	molecular_function	molecular_function
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008033	biological_process	tRNA processing
B	0008198	molecular_function	ferrous iron binding
B	0008270	molecular_function	zinc ion binding
B	0016491	molecular_function	oxidoreductase activity
B	0016567	biological_process	protein ubiquitination
B	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
B	0017183	biological_process	protein histidyl modification to diphthamide
B	0034986	molecular_function	iron chaperone activity
B	0046872	molecular_function	metal ion binding
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity
C	0002098	biological_process	tRNA wobble uridine modification
C	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
C	0003674	molecular_function	molecular_function
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0008033	biological_process	tRNA processing
C	0008198	molecular_function	ferrous iron binding
C	0008270	molecular_function	zinc ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0016567	biological_process	protein ubiquitination
C	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
C	0017183	biological_process	protein histidyl modification to diphthamide
C	0034986	molecular_function	iron chaperone activity
C	0046872	molecular_function	metal ion binding
C	0061630	molecular_function	ubiquitin protein ligase activity
C	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity
E	0002098	biological_process	tRNA wobble uridine modification
E	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
E	0003674	molecular_function	molecular_function
E	0005506	molecular_function	iron ion binding
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0008033	biological_process	tRNA processing
E	0008198	molecular_function	ferrous iron binding
E	0008270	molecular_function	zinc ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0016567	biological_process	protein ubiquitination
E	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
E	0017183	biological_process	protein histidyl modification to diphthamide
E	0034986	molecular_function	iron chaperone activity
E	0046872	molecular_function	metal ion binding
E	0061630	molecular_function	ubiquitin protein ligase activity
E	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity
G	0002098	biological_process	tRNA wobble uridine modification
G	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
G	0003674	molecular_function	molecular_function
G	0005506	molecular_function	iron ion binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0008033	biological_process	tRNA processing
G	0008198	molecular_function	ferrous iron binding
G	0008270	molecular_function	zinc ion binding
G	0016491	molecular_function	oxidoreductase activity
G	0016567	biological_process	protein ubiquitination
G	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
G	0017183	biological_process	protein histidyl modification to diphthamide
G	0034986	molecular_function	iron chaperone activity
G	0046872	molecular_function	metal ion binding
G	0061630	molecular_function	ubiquitin protein ligase activity
G	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity
H	0002098	biological_process	tRNA wobble uridine modification
H	0002926	biological_process	tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation
H	0003674	molecular_function	molecular_function
H	0005506	molecular_function	iron ion binding
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008033	biological_process	tRNA processing
H	0008198	molecular_function	ferrous iron binding
H	0008270	molecular_function	zinc ion binding
H	0016491	molecular_function	oxidoreductase activity
H	0016567	biological_process	protein ubiquitination
H	0016730	molecular_function	oxidoreductase activity, acting on iron-sulfur proteins as donors
H	0017183	biological_process	protein histidyl modification to diphthamide
H	0034986	molecular_function	iron chaperone activity
H	0046872	molecular_function	metal ion binding
H	0061630	molecular_function	ubiquitin protein ligase activity
H	0090560	molecular_function	2-(3-amino-3-carboxypropyl)histidine synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE A 501

Chain	Residue
A	CYS368
A	CYS370
A	CYS390
A	CYS393

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 501

Chain	Residue
C	CYS368
C	CYS370
C	CYS390
C	CYS393

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1418

Chain	Residue
A	GLN120
A	ARG107

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 1336

Chain	Residue
B	ARG107
B	GLN120

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 1337

Chain	Residue
B	ARG220
B	ASN236
B	ARG238

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 E 1335

Chain	Residue
E	ARG107
E	GLN120

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 E 1336

Chain	Residue
E	ARG220
E	ASN236
E	ARG238

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE G 501

Chain	Residue
G	CYS368
G	CYS370
G	CYS390
G	CYS393

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE H 501

Chain	Residue
H	CYS368
H	CYS370
H	CYS390
H	CYS393

Functional Information from PROSITE/UniProt

site_id	PS00626
Number of Residues	11
Details	RCC1_2 Regulator of chromosome condensation (RCC1) signature 2. IACGgNHSVML

Chain	Residue	Details
A	ILE41-LEU51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Repeat: {"description":"RCC1 1"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	196
Details	Repeat: {"description":"RCC1 2"}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	204
Details	Repeat: {"description":"RCC1 3"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	188
Details	Repeat: {"description":"RCC1 4"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	168
Details	Domain: {"description":"DPH-type MB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00456","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25543256","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25604895","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4D4O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4D4P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4X33","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)