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4D3U

Structure of Bacillus subtilis Nitric Oxide Synthase H128S in complex with N-{3-[(1S)-2-(3-{(Z)-[amino(thiophen-2-yl)methylidene]amino}phenoxy)-1-hydroxyethyl]phenyl}thiophene-2-carboximidamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0004517molecular_functionnitric-oxide synthase activity
A0005575cellular_componentcellular_component
A0006809biological_processnitric oxide biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE POL A 906
ChainResidue
AGLY144
ALYS257

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE POL A 907
ChainResidue
ATRP327
ATHR328
ATRP329
ASER345
ARFQ904

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE POL A 909
ChainResidue
AASN248
AHEM901
ACL903
ARFQ904
AHOH2166
AGLU243
AARG247

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE HEM A 901
ChainResidue
ATRP60
ASER63
AARG65
ACYS66
APHE235
AASN236
ATRP238
AGLU243
ATRP329
ATYR355
ATYR357
ARFQ904
AGOL908
APOL909
AHOH2166

site_idAC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 905
ChainResidue
AGLY159
ATRP160
AARG161
ASER298
AILE299
AGLN308
AHOH2168

site_idAC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 908
ChainResidue
AILE350
ATYR355
APHE356
ATYR357
AHEM901
AHOH2169

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 903
ChainResidue
AGLN129
ATYR239
AASN248
APOL909

site_idAC8
Number of Residues15
DetailsBINDING SITE FOR RESIDUE RFQ A 904
ChainResidue
APRO216
AILE218
APHE235
AASN236
AGLY237
ATRP238
AGLU243
AARG247
ATHR328
ATRP329
APHE342
AHEM901
APOL907
APOL909
AHOH2043

Functional Information from PROSITE/UniProt
site_idPS60001
Number of Residues8
DetailsNOS Nitric oxide synthase (NOS) signature. RCIGRLfW
ChainResidueDetails
AARG65-TRP72

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue
ChainResidueDetails
ACYS66

226707

PDB entries from 2024-10-30

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