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4CYF

The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

Functional Information from GO Data
ChainGOidnamespacecontents
A0002526biological_processacute inflammatory response
A0002544biological_processchronic inflammatory response
A0005576cellular_componentextracellular region
A0005886cellular_componentplasma membrane
A0006807biological_processobsolete nitrogen compound metabolic process
A0006954biological_processinflammatory response
A0006979biological_processresponse to oxidative stress
A0015938biological_processcoenzyme A catabolic process
A0015939biological_processpantothenate metabolic process
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0016811molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
A0017159molecular_functionpantetheine hydrolase activity
A0033089biological_processpositive regulation of T cell differentiation in thymus
A0035577cellular_componentazurophil granule membrane
A0045087biological_processinnate immune response
A0098552cellular_componentside of membrane
A0098609biological_processcell-cell adhesion
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B0002526biological_processacute inflammatory response
B0002544biological_processchronic inflammatory response
B0005576cellular_componentextracellular region
B0005886cellular_componentplasma membrane
B0006807biological_processobsolete nitrogen compound metabolic process
B0006954biological_processinflammatory response
B0006979biological_processresponse to oxidative stress
B0015938biological_processcoenzyme A catabolic process
B0015939biological_processpantothenate metabolic process
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0016811molecular_functionhydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
B0017159molecular_functionpantetheine hydrolase activity
B0033089biological_processpositive regulation of T cell differentiation in thymus
B0035577cellular_componentazurophil granule membrane
B0045087biological_processinnate immune response
B0098552cellular_componentside of membrane
B0098609biological_processcell-cell adhesion
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000305|PubMed:25478849
ChainResidueDetails
AGLU79
BGLU79

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Proton donor => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000305|PubMed:25478849
ChainResidueDetails
ALYS178
BLYS178

site_idSWS_FT_FI3
Number of Residues2
DetailsACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00054, ECO:0000269|PubMed:25478849
ChainResidueDetails
ACSO211
BCSO211

site_idSWS_FT_FI4
Number of Residues2
DetailsLIPID: GPI-anchor amidated glycine => ECO:0000255
ChainResidueDetails
AGLY491
BGLY491

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY
ChainResidueDetails
BASN38
AASN38

site_idSWS_FT_FI6
Number of Residues4
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY
ChainResidueDetails
AASN130
AASN315
BASN130
BASN315

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255, ECO:0007744|PDB:4CYY
ChainResidueDetails
AASN200
BASN200

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952
ChainResidueDetails
AASN283
BASN283

site_idSWS_FT_FI9
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0007744|PDB:4CYF, ECO:0007744|PDB:4CYG, ECO:0007744|PDB:4CYY
ChainResidueDetails
AASN353
BASN353

220472

PDB entries from 2024-05-29

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