4CY4

The Cryo-Electron Microscopy Structure of the CorA channel from Methanocaldococcus jannaschii at 21.6 Angstrom in low magnesium.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0042802	molecular_function	identical protein binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0042802	molecular_function	identical protein binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0042802	molecular_function	identical protein binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0042802	molecular_function	identical protein binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0042802	molecular_function	identical protein binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1310
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	MET1-LYS258
E	ARG312-ILE317
A	ARG312-ILE317
B	MET1-LYS258
B	ARG312-ILE317
C	MET1-LYS258
C	ARG312-ILE317
D	MET1-LYS258
D	ARG312-ILE317
E	MET1-LYS258

---

site_id	SWS_FT_FI2
Number of Residues	200
Details	TRANSMEM: Helical => ECO:0000269|PubMed:23091000

Chain	Residue	Details
A	ILE259-MET279
E	GLN291-PHE311
A	GLN291-PHE311
B	ILE259-MET279
B	GLN291-PHE311
C	ILE259-MET279
C	GLN291-PHE311
D	ILE259-MET279
D	GLN291-PHE311
E	ILE259-MET279

---

site_id	SWS_FT_FI3
Number of Residues	50
Details	TOPO_DOM: Extracellular => ECO:0000305

Chain	Residue	Details
A	ASN280-PRO290
B	ASN280-PRO290
C	ASN280-PRO290
D	ASN280-PRO290
E	ASN280-PRO290

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	SITE: Essential for ion permeation => ECO:0000250|UniProtKB:Q9WZ31

Chain	Residue	Details
A	ASN254
B	ASN254
C	ASN254
D	ASN254
E	ASN254

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site_id	SWS_FT_FI5
Number of Residues	5
Details	SITE: Important for closing the ion permeation pathway in the closed state => ECO:0000269|PubMed:23091000

Chain	Residue	Details
A	LEU260
B	LEU260
C	LEU260
D	LEU260
E	LEU260

---

site_id	SWS_FT_FI6
Number of Residues	5
Details	SITE: Threonine that confers selectivity for Co(2+) transport => ECO:0000250|UniProtKB:Q9WZ31

Chain	Residue	Details
A	THR261
B	THR261
C	THR261
D	THR261
E	THR261

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