4CXG
Regulation of the mammalian elongation cycle by 40S subunit rolling: a eukaryotic-specific ribosome rearrangement
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003746 | molecular_function | translation elongation factor activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006412 | biological_process | translation |
| A | 0006414 | biological_process | translational elongation |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046872 | molecular_function | metal ion binding |
| X | 0002181 | biological_process | cytoplasmic translation |
| X | 0003723 | molecular_function | RNA binding |
| X | 0003735 | molecular_function | structural constituent of ribosome |
| X | 0005515 | molecular_function | protein binding |
| X | 0005634 | cellular_component | nucleus |
| X | 0005654 | cellular_component | nucleoplasm |
| X | 0005730 | cellular_component | nucleolus |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005783 | cellular_component | endoplasmic reticulum |
| X | 0005791 | cellular_component | rough endoplasmic reticulum |
| X | 0005829 | cellular_component | cytosol |
| X | 0005840 | cellular_component | ribosome |
| X | 0006412 | biological_process | translation |
| X | 0015935 | cellular_component | small ribosomal subunit |
| X | 0016020 | cellular_component | membrane |
| X | 0022626 | cellular_component | cytosolic ribosome |
| X | 0022627 | cellular_component | cytosolic small ribosomal subunit |
| X | 0032040 | cellular_component | small-subunit processome |
| X | 0034063 | biological_process | stress granule assembly |
| X | 0042274 | biological_process | ribosomal small subunit biogenesis |
| X | 0045202 | cellular_component | synapse |
| X | 1990145 | biological_process | maintenance of translational fidelity |
| X | 1990904 | cellular_component | ribonucleoprotein complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PHE Y 77 |
| Chain | Residue |
| A | TYR241 |
| Y | A76 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 225 |
| Details | Domain: {"description":"tr-type G"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Region: {"description":"G1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"G2","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Region: {"description":"G3","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Region: {"description":"G4","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Region: {"description":"G5","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 15 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00118","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62267","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"3-hydroxyproline","evidences":[{"source":"PubMed","id":"24550447","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24550462","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28257692","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
