4CT0
Crystal Structure of Mouse Cryptochrome1 in Complex with Period2
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1497 |
| Chain | Residue |
| A | CYS414 |
| A | HIS473 |
| B | CYS1210 |
| B | CYS1213 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1498 |
| Chain | Residue |
| A | SER102 |
| A | HOH2060 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P6G A 1499 |
| Chain | Residue |
| A | GLU108 |
| B | GLU1183 |
| A | ASP38 |
| A | TRP40 |
| A | PHE105 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 129 |
| Details | Domain: {"description":"Photolyase/cryptochrome alpha/beta"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 99 |
| Details | Region: {"description":"Required for inhibition of CLOCK-BMAL1-mediated transcription","evidences":[{"source":"PubMed","id":"16478995","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 22 |
| Details | Region: {"description":"Interaction with TIMELESS","evidences":[{"source":"PubMed","id":"23418588","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LIR 1","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 2","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 3","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 4","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 5","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 6","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Motif: {"description":"LIR 7","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 8","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 9","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 10","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 11","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 5 |
| Details | Motif: {"description":"LIR 12","evidences":[{"source":"PubMed","id":"29937374","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23746849","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by AMPK","evidences":[{"source":"PubMed","id":"19833968","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI18 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK","evidences":[{"source":"PubMed","id":"15298678","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452855","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI20 |
| Number of Residues | 5 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"23452856","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
