4CR8

Crystal structure of the N-acetyl-D-mannosamine dehydrogenase with NAD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
B	0016491	molecular_function	oxidoreductase activity
B	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
C	0016491	molecular_function	oxidoreductase activity
C	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
D	0016491	molecular_function	oxidoreductase activity
D	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
E	0016491	molecular_function	oxidoreductase activity
E	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
F	0016491	molecular_function	oxidoreductase activity
F	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
G	0016491	molecular_function	oxidoreductase activity
G	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity
H	0016491	molecular_function	oxidoreductase activity
H	0050123	molecular_function	N-acylmannosamine 1-dehydrogenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NAD A 1272

Chain	Residue
A	GLY25
A	GLY95
A	ALA96
A	HOH2006
A	HOH2111
A	GLY26
A	ILE27
A	ASP46
A	LEU47
A	ARG50
A	CYS66
A	ASP67
A	LEU68

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD B 1272

Chain	Residue
B	GLY25
B	GLY26
B	ILE27
B	ASP46
B	LEU47
B	ARG50
B	CYS66
B	ASP67
B	LEU68
B	GLY95
B	ALA96
B	HOH2008
B	HOH2009
B	HOH2011

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE NAD C 1272

Chain	Residue
C	GLY25
C	GLY26
C	ILE27
C	ASP46
C	LEU47
C	ARG50
C	CYS66
C	ASP67
C	LEU68
C	GLY95
C	ALA96
C	HOH2006

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE NAD D 1272

Chain	Residue
D	ALA24
D	GLY25
D	GLY26
D	ILE27
D	ASP46
D	LEU47
D	ARG50
D	CYS66
D	ASP67
D	LEU68
D	GLY95
D	ALA96
D	HOH2006
D	HOH2007
D	HOH2014

---

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE NAD E 1272

Chain	Residue
E	ALA24
E	GLY25
E	GLY26
E	ILE27
E	ASP46
E	LEU47
E	ARG50
E	CYS66
E	ASP67
E	LEU68
E	GLY95
E	ALA96
E	HOH2006
E	HOH2007

---

site_id	AC6
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NAD F 1272

Chain	Residue
F	GLY25
F	GLY26
F	ILE27
F	ASP46
F	LEU47
F	ARG50
F	CYS66
F	ASP67
F	LEU68
F	GLY95
F	ALA96
F	HOH2004
F	HOH2024

---

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NAD G 1272

Chain	Residue
G	GLY25
G	GLY26
G	ILE27
G	ASP46
G	LEU47
G	ARG50
G	CYS66
G	ASP67
G	LEU68
G	GLY95
G	ALA96
G	HOH2007
G	HOH2010

---

site_id	AC8
Number of Residues	13
Details	BINDING SITE FOR RESIDUE NAD H 1272

Chain	Residue
H	ARG50
H	CYS66
H	ASP67
H	LEU68
H	GLY95
H	ALA96
H	HOH2006
H	HOH2065
H	GLY25
H	GLY26
H	ILE27
H	ASP46
H	LEU47

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvnsfmaepeAaaYVAAKGGVaMLTrAMA

Chain	Residue	Details
A	SER153-ALA181

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR166
B	TYR166
C	TYR166
D	TYR166
E	TYR166
F	TYR166
G	TYR166
H	TYR166

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	VAL20
E	SER153
F	VAL20
F	SER153
G	VAL20
G	SER153
H	VAL20
H	SER153
A	SER153
B	VAL20
B	SER153
C	VAL20
C	SER153
D	VAL20
D	SER153
E	VAL20

---