4COK
Functional and Structural Characterization of Pyruvate decarboxylase from Gluconoacetobacter diazotrophicus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE TPP A 600 |
| Chain | Residue |
| A | GLY385 |
| A | ASN463 |
| A | GLY465 |
| A | TYR466 |
| A | THR467 |
| A | ILE468 |
| A | GLU469 |
| A | MG601 |
| A | HOH2367 |
| A | HOH2479 |
| A | HOH2480 |
| A | ASP386 |
| A | HOH2515 |
| A | HOH2630 |
| B | ALA25 |
| B | GLY26 |
| B | GLU50 |
| B | VAL75 |
| B | HIS114 |
| A | GLY409 |
| A | HIS410 |
| A | ILE411 |
| A | GLY435 |
| A | ASP436 |
| A | GLY437 |
| A | SER438 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 601 |
| Chain | Residue |
| A | ASP436 |
| A | ASN463 |
| A | GLY465 |
| A | TPP600 |
| A | HOH2515 |
| site_id | AC3 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE TPP B 600 |
| Chain | Residue |
| A | ALA25 |
| A | GLY26 |
| A | GLU50 |
| A | VAL75 |
| A | HIS114 |
| A | HOH2147 |
| B | GLY385 |
| B | ASP386 |
| B | GLY409 |
| B | HIS410 |
| B | ILE411 |
| B | GLY435 |
| B | ASP436 |
| B | GLY437 |
| B | SER438 |
| B | ASN463 |
| B | GLY465 |
| B | TYR466 |
| B | THR467 |
| B | ILE468 |
| B | GLU469 |
| B | MG601 |
| B | HOH2406 |
| B | HOH2407 |
| B | HOH2437 |
| B | HOH2535 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 601 |
| Chain | Residue |
| B | ASP436 |
| B | ASN463 |
| B | GLY465 |
| B | TPP600 |
| B | HOH2437 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1556 |
| Chain | Residue |
| A | LEU373 |
| A | GLN429 |
| A | ARG518 |
| A | HOH2469 |
| A | HOH2597 |
| A | HOH2631 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1557 |
| Chain | Residue |
| A | ARG377 |
| A | GLN429 |
| B | HIS398 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGnalaaPerqhVlMvGDGS |
| Chain | Residue | Details |
| A | PHE419-SER438 |
