4COK
Functional and Structural Characterization of Pyruvate decarboxylase from Gluconoacetobacter diazotrophicus
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
A | 0003824 | molecular_function | catalytic activity |
A | 0004737 | molecular_function | pyruvate decarboxylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0016831 | molecular_function | carboxy-lyase activity |
A | 0019752 | biological_process | carboxylic acid metabolic process |
A | 0030976 | molecular_function | thiamine pyrophosphate binding |
A | 0046872 | molecular_function | metal ion binding |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
B | 0003824 | molecular_function | catalytic activity |
B | 0004737 | molecular_function | pyruvate decarboxylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0016831 | molecular_function | carboxy-lyase activity |
B | 0019752 | biological_process | carboxylic acid metabolic process |
B | 0030976 | molecular_function | thiamine pyrophosphate binding |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE TPP A 600 |
Chain | Residue |
A | GLY385 |
A | ASN463 |
A | GLY465 |
A | TYR466 |
A | THR467 |
A | ILE468 |
A | GLU469 |
A | MG601 |
A | HOH2367 |
A | HOH2479 |
A | HOH2480 |
A | ASP386 |
A | HOH2515 |
A | HOH2630 |
B | ALA25 |
B | GLY26 |
B | GLU50 |
B | VAL75 |
B | HIS114 |
A | GLY409 |
A | HIS410 |
A | ILE411 |
A | GLY435 |
A | ASP436 |
A | GLY437 |
A | SER438 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG A 601 |
Chain | Residue |
A | ASP436 |
A | ASN463 |
A | GLY465 |
A | TPP600 |
A | HOH2515 |
site_id | AC3 |
Number of Residues | 26 |
Details | BINDING SITE FOR RESIDUE TPP B 600 |
Chain | Residue |
A | ALA25 |
A | GLY26 |
A | GLU50 |
A | VAL75 |
A | HIS114 |
A | HOH2147 |
B | GLY385 |
B | ASP386 |
B | GLY409 |
B | HIS410 |
B | ILE411 |
B | GLY435 |
B | ASP436 |
B | GLY437 |
B | SER438 |
B | ASN463 |
B | GLY465 |
B | TYR466 |
B | THR467 |
B | ILE468 |
B | GLU469 |
B | MG601 |
B | HOH2406 |
B | HOH2407 |
B | HOH2437 |
B | HOH2535 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MG B 601 |
Chain | Residue |
B | ASP436 |
B | ASN463 |
B | GLY465 |
B | TPP600 |
B | HOH2437 |
site_id | AC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE SO4 A 1556 |
Chain | Residue |
A | LEU373 |
A | GLN429 |
A | ARG518 |
A | HOH2469 |
A | HOH2597 |
A | HOH2631 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE SO4 A 1557 |
Chain | Residue |
A | ARG377 |
A | GLN429 |
B | HIS398 |
Functional Information from PROSITE/UniProt
site_id | PS00187 |
Number of Residues | 20 |
Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FGnalaaPerqhVlMvGDGS |
Chain | Residue | Details |
A | PHE419-SER438 |