4CNV

Surface residue engineering of bovine carbonic anhydrase to an extreme halophilic enzyme for potential application in postcombustion CO2 capture

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004089	molecular_function	carbonate dehydratase activity
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006730	biological_process	one-carbon metabolic process
A	0008270	molecular_function	zinc ion binding
A	0015670	biological_process	carbon dioxide transport
A	0016829	molecular_function	lyase activity
A	0018820	molecular_function	cyanamide hydratase activity
A	0038166	biological_process	angiotensin-activated signaling pathway
A	0044070	biological_process	regulation of monoatomic anion transport
A	0045177	cellular_component	apical part of cell
A	0046872	molecular_function	metal ion binding
A	0051453	biological_process	regulation of intracellular pH
A	2001150	biological_process	positive regulation of dipeptide transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 268

Chain	Residue
A	HIS94
A	HIS96
A	HIS119
A	HOH2110
A	HOH2111

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 1001

Chain	Residue
A	HOH2249
A	ASP32
A	ASP34
A	ASP110
A	ARG111

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 1002

Chain	Residue
A	ASP34
A	LYS36

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Functional Information from PROSITE/UniProt

site_id	PS00162
Number of Residues	17
Details	ALPHA_CA_1 Alpha-carbonic anhydrases signature. SEHtVdrkkYaaELHLV

Chain	Residue	Details
A	SER105-VAL121

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	HIS64

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:15039588

Chain	Residue	Details
A	HIS94
A	HIS96
A	HIS119

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	THR198

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site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Fine-tunes the proton-transfer properties of H-64 => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	TYR7
A	ASN62
A	ASN67

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P27139

Chain	Residue	Details
A	SER2

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site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P00918

Chain	Residue	Details
A	SER165
A	SER172

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