4CNT

CRYSTAL STRUCTURE OF WT HUMAN CRMP-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004157	molecular_function	dihydropyrimidinase activity
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006208	biological_process	pyrimidine nucleobase catabolic process
A	0010976	biological_process	positive regulation of neuron projection development
A	0010977	biological_process	negative regulation of neuron projection development
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0017124	molecular_function	SH3 domain binding
A	0030027	cellular_component	lamellipodium
A	0030336	biological_process	negative regulation of cell migration
A	0030426	cellular_component	growth cone
A	0031005	molecular_function	filamin binding
A	0031941	cellular_component	filamentous actin
A	0035374	molecular_function	chondroitin sulfate binding
A	0042802	molecular_function	identical protein binding
A	0044297	cellular_component	cell body
A	0045202	cellular_component	synapse
A	0048666	biological_process	neuron development
A	0048678	biological_process	response to axon injury
A	0051017	biological_process	actin filament bundle assembly
A	0051219	molecular_function	phosphoprotein binding
A	0051491	biological_process	positive regulation of filopodium assembly
A	0051764	biological_process	actin crosslink formation
A	0070382	cellular_component	exocytic vesicle
A	0071345	biological_process	cellular response to cytokine stimulus
B	0004157	molecular_function	dihydropyrimidinase activity
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006208	biological_process	pyrimidine nucleobase catabolic process
B	0010976	biological_process	positive regulation of neuron projection development
B	0010977	biological_process	negative regulation of neuron projection development
B	0016787	molecular_function	hydrolase activity
B	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
B	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B	0017124	molecular_function	SH3 domain binding
B	0030027	cellular_component	lamellipodium
B	0030336	biological_process	negative regulation of cell migration
B	0030426	cellular_component	growth cone
B	0031005	molecular_function	filamin binding
B	0031941	cellular_component	filamentous actin
B	0035374	molecular_function	chondroitin sulfate binding
B	0042802	molecular_function	identical protein binding
B	0044297	cellular_component	cell body
B	0045202	cellular_component	synapse
B	0048666	biological_process	neuron development
B	0048678	biological_process	response to axon injury
B	0051017	biological_process	actin filament bundle assembly
B	0051219	molecular_function	phosphoprotein binding
B	0051491	biological_process	positive regulation of filopodium assembly
B	0051764	biological_process	actin crosslink formation
B	0070382	cellular_component	exocytic vesicle
B	0071345	biological_process	cellular response to cytokine stimulus
C	0004157	molecular_function	dihydropyrimidinase activity
C	0005515	molecular_function	protein binding
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006208	biological_process	pyrimidine nucleobase catabolic process
C	0010976	biological_process	positive regulation of neuron projection development
C	0010977	biological_process	negative regulation of neuron projection development
C	0016787	molecular_function	hydrolase activity
C	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
C	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C	0017124	molecular_function	SH3 domain binding
C	0030027	cellular_component	lamellipodium
C	0030336	biological_process	negative regulation of cell migration
C	0030426	cellular_component	growth cone
C	0031005	molecular_function	filamin binding
C	0031941	cellular_component	filamentous actin
C	0035374	molecular_function	chondroitin sulfate binding
C	0042802	molecular_function	identical protein binding
C	0044297	cellular_component	cell body
C	0045202	cellular_component	synapse
C	0048666	biological_process	neuron development
C	0048678	biological_process	response to axon injury
C	0051017	biological_process	actin filament bundle assembly
C	0051219	molecular_function	phosphoprotein binding
C	0051491	biological_process	positive regulation of filopodium assembly
C	0051764	biological_process	actin crosslink formation
C	0070382	cellular_component	exocytic vesicle
C	0071345	biological_process	cellular response to cytokine stimulus
D	0004157	molecular_function	dihydropyrimidinase activity
D	0005515	molecular_function	protein binding
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006208	biological_process	pyrimidine nucleobase catabolic process
D	0010976	biological_process	positive regulation of neuron projection development
D	0010977	biological_process	negative regulation of neuron projection development
D	0016787	molecular_function	hydrolase activity
D	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
D	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D	0017124	molecular_function	SH3 domain binding
D	0030027	cellular_component	lamellipodium
D	0030336	biological_process	negative regulation of cell migration
D	0030426	cellular_component	growth cone
D	0031005	molecular_function	filamin binding
D	0031941	cellular_component	filamentous actin
D	0035374	molecular_function	chondroitin sulfate binding
D	0042802	molecular_function	identical protein binding
D	0044297	cellular_component	cell body
D	0045202	cellular_component	synapse
D	0048666	biological_process	neuron development
D	0048678	biological_process	response to axon injury
D	0051017	biological_process	actin filament bundle assembly
D	0051219	molecular_function	phosphoprotein binding
D	0051491	biological_process	positive regulation of filopodium assembly
D	0051764	biological_process	actin crosslink formation
D	0070382	cellular_component	exocytic vesicle
D	0071345	biological_process	cellular response to cytokine stimulus

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 1497

Chain	Residue
D	ASP128
D	GLY464
D	GLY466

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1497

Chain	Residue
A	TRP144
A	ASP146

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q62188","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17081983","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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