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4CNI

Crystal structure of the Fab portion of Olokizumab in complex with IL- 6

Functional Information from GO Data
ChainGOidnamespacecontents
C0001781biological_processneutrophil apoptotic process
C0002314biological_processgerminal center B cell differentiation
C0002384biological_processhepatic immune response
C0002446biological_processneutrophil mediated immunity
C0002548biological_processmonocyte chemotaxis
C0002639biological_processpositive regulation of immunoglobulin production
C0002675biological_processpositive regulation of acute inflammatory response
C0002690biological_processpositive regulation of leukocyte chemotaxis
C0005102molecular_functionsignaling receptor binding
C0005125molecular_functioncytokine activity
C0005138molecular_functioninterleukin-6 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005788cellular_componentendoplasmic reticulum lumen
C0005896cellular_componentinterleukin-6 receptor complex
C0006953biological_processacute-phase response
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0006959biological_processhumoral immune response
C0008083molecular_functiongrowth factor activity
C0008284biological_processpositive regulation of cell population proliferation
C0008285biological_processnegative regulation of cell population proliferation
C0010573biological_processvascular endothelial growth factor production
C0010574biological_processregulation of vascular endothelial growth factor production
C0010575biological_processpositive regulation of vascular endothelial growth factor production
C0010628biological_processpositive regulation of gene expression
C0010718biological_processpositive regulation of epithelial to mesenchymal transition
C0010888biological_processnegative regulation of lipid storage
C0014823biological_processresponse to activity
C0019221biological_processcytokine-mediated signaling pathway
C0030154biological_processcell differentiation
C0030168biological_processplatelet activation
C0031018biological_processendocrine pancreas development
C0031175biological_processneuron projection development
C0032494biological_processresponse to peptidoglycan
C0032682biological_processnegative regulation of chemokine production
C0032722biological_processpositive regulation of chemokine production
C0032731biological_processpositive regulation of interleukin-1 beta production
C0032733biological_processpositive regulation of interleukin-10 production
C0032740biological_processpositive regulation of interleukin-17 production
C0032745biological_processpositive regulation of interleukin-21 production
C0032755biological_processpositive regulation of interleukin-6 production
C0032757biological_processpositive regulation of interleukin-8 production
C0032760biological_processpositive regulation of tumor necrosis factor production
C0032966biological_processnegative regulation of collagen biosynthetic process
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0035633biological_processmaintenance of blood-brain barrier
C0042102biological_processpositive regulation of T cell proliferation
C0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
C0042593biological_processglucose homeostasis
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043066biological_processnegative regulation of apoptotic process
C0043410biological_processpositive regulation of MAPK cascade
C0045599biological_processnegative regulation of fat cell differentiation
C0045669biological_processpositive regulation of osteoblast differentiation
C0045727biological_processpositive regulation of translation
C0045765biological_processregulation of angiogenesis
C0045779biological_processnegative regulation of bone resorption
C0045893biological_processpositive regulation of DNA-templated transcription
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0048661biological_processpositive regulation of smooth muscle cell proliferation
C0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
C0050768biological_processnegative regulation of neurogenesis
C0050796biological_processregulation of insulin secretion
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0050871biological_processpositive regulation of B cell activation
C0051091biological_processpositive regulation of DNA-binding transcription factor activity
C0051092biological_processpositive regulation of NF-kappaB transcription factor activity
C0051240biological_processpositive regulation of multicellular organismal process
C0051384biological_processresponse to glucocorticoid
C0051607biological_processdefense response to virus
C0060252biological_processpositive regulation of glial cell proliferation
C0061470biological_processT follicular helper cell differentiation
C0061888biological_processregulation of astrocyte activation
C0070050biological_processneuron cellular homeostasis
C0070091biological_processglucagon secretion
C0070092biological_processregulation of glucagon secretion
C0070102biological_processinterleukin-6-mediated signaling pathway
C0070301biological_processcellular response to hydrogen peroxide
C0071222biological_processcellular response to lipopolysaccharide
C0072540biological_processT-helper 17 cell lineage commitment
C0072574biological_processhepatocyte proliferation
C0090091biological_processpositive regulation of extracellular matrix disassembly
C0090594biological_processinflammatory response to wounding
C0097421biological_processliver regeneration
C0097696biological_processcell surface receptor signaling pathway via STAT
C0098586biological_processcellular response to virus
C0150077biological_processregulation of neuroinflammatory response
C0150078biological_processpositive regulation of neuroinflammatory response
C1900017biological_processpositive regulation of cytokine production involved in inflammatory response
C1901731biological_processpositive regulation of platelet aggregation
C1902512biological_processpositive regulation of apoptotic DNA fragmentation
C1903978biological_processregulation of microglial cell activation
C1904894biological_processpositive regulation of receptor signaling pathway via STAT
C1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
C2000553biological_processpositive regulation of T-helper 2 cell cytokine production
C2000635biological_processnegative regulation of primary miRNA processing
C2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
C2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
D0001781biological_processneutrophil apoptotic process
D0002314biological_processgerminal center B cell differentiation
D0002384biological_processhepatic immune response
D0002446biological_processneutrophil mediated immunity
D0002548biological_processmonocyte chemotaxis
D0002639biological_processpositive regulation of immunoglobulin production
D0002675biological_processpositive regulation of acute inflammatory response
D0002690biological_processpositive regulation of leukocyte chemotaxis
D0005102molecular_functionsignaling receptor binding
D0005125molecular_functioncytokine activity
D0005138molecular_functioninterleukin-6 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005788cellular_componentendoplasmic reticulum lumen
D0005896cellular_componentinterleukin-6 receptor complex
D0006953biological_processacute-phase response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0006959biological_processhumoral immune response
D0008083molecular_functiongrowth factor activity
D0008284biological_processpositive regulation of cell population proliferation
D0008285biological_processnegative regulation of cell population proliferation
D0010573biological_processvascular endothelial growth factor production
D0010574biological_processregulation of vascular endothelial growth factor production
D0010575biological_processpositive regulation of vascular endothelial growth factor production
D0010628biological_processpositive regulation of gene expression
D0010718biological_processpositive regulation of epithelial to mesenchymal transition
D0010888biological_processnegative regulation of lipid storage
D0014823biological_processresponse to activity
D0019221biological_processcytokine-mediated signaling pathway
D0030154biological_processcell differentiation
D0030168biological_processplatelet activation
D0031018biological_processendocrine pancreas development
D0031175biological_processneuron projection development
D0032494biological_processresponse to peptidoglycan
D0032682biological_processnegative regulation of chemokine production
D0032722biological_processpositive regulation of chemokine production
D0032731biological_processpositive regulation of interleukin-1 beta production
D0032733biological_processpositive regulation of interleukin-10 production
D0032740biological_processpositive regulation of interleukin-17 production
D0032745biological_processpositive regulation of interleukin-21 production
D0032755biological_processpositive regulation of interleukin-6 production
D0032757biological_processpositive regulation of interleukin-8 production
D0032760biological_processpositive regulation of tumor necrosis factor production
D0032966biological_processnegative regulation of collagen biosynthetic process
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0035633biological_processmaintenance of blood-brain barrier
D0042102biological_processpositive regulation of T cell proliferation
D0042531biological_processpositive regulation of tyrosine phosphorylation of STAT protein
D0042593biological_processglucose homeostasis
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043066biological_processnegative regulation of apoptotic process
D0043410biological_processpositive regulation of MAPK cascade
D0045599biological_processnegative regulation of fat cell differentiation
D0045669biological_processpositive regulation of osteoblast differentiation
D0045727biological_processpositive regulation of translation
D0045765biological_processregulation of angiogenesis
D0045779biological_processnegative regulation of bone resorption
D0045893biological_processpositive regulation of DNA-templated transcription
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0048661biological_processpositive regulation of smooth muscle cell proliferation
D0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
D0050768biological_processnegative regulation of neurogenesis
D0050796biological_processregulation of insulin secretion
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0050871biological_processpositive regulation of B cell activation
D0051091biological_processpositive regulation of DNA-binding transcription factor activity
D0051092biological_processpositive regulation of NF-kappaB transcription factor activity
D0051240biological_processpositive regulation of multicellular organismal process
D0051384biological_processresponse to glucocorticoid
D0051607biological_processdefense response to virus
D0060252biological_processpositive regulation of glial cell proliferation
D0061470biological_processT follicular helper cell differentiation
D0061888biological_processregulation of astrocyte activation
D0070050biological_processneuron cellular homeostasis
D0070091biological_processglucagon secretion
D0070092biological_processregulation of glucagon secretion
D0070102biological_processinterleukin-6-mediated signaling pathway
D0070301biological_processcellular response to hydrogen peroxide
D0071222biological_processcellular response to lipopolysaccharide
D0072540biological_processT-helper 17 cell lineage commitment
D0072574biological_processhepatocyte proliferation
D0090091biological_processpositive regulation of extracellular matrix disassembly
D0090594biological_processinflammatory response to wounding
D0097421biological_processliver regeneration
D0097696biological_processcell surface receptor signaling pathway via STAT
D0098586biological_processcellular response to virus
D0150077biological_processregulation of neuroinflammatory response
D0150078biological_processpositive regulation of neuroinflammatory response
D1900017biological_processpositive regulation of cytokine production involved in inflammatory response
D1901731biological_processpositive regulation of platelet aggregation
D1902512biological_processpositive regulation of apoptotic DNA fragmentation
D1903978biological_processregulation of microglial cell activation
D1904894biological_processpositive regulation of receptor signaling pathway via STAT
D1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
D2000553biological_processpositive regulation of T-helper 2 cell cytokine production
D2000635biological_processnegative regulation of primary miRNA processing
D2000660biological_processnegative regulation of interleukin-1-mediated signaling pathway
D2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
Functional Information from PDB Data
site_idAC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE TAM A 1221
ChainResidue
ATYR32
AARG100
AGLU101
ASER102
ATYR103
ASER108
AHOH2069
AHOH2351
AHOH2353

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 C 1185
ChainResidue
BSER60
BHOH2104
CARG40
CHIS164
CARG168
CHOH2194

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 C 1186
ChainResidue
ASER122
AHOH2214
CPRO18
CLEU19
CARG24
CHOH2010
CHOH2029

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 D 1185
ChainResidue
DARG40
DHIS164
DHOH2180
DHOH2191
DHOH2192
LSER60

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 D 1186
ChainResidue
DPRO18
DLEU19
DHOH2011
DHOH2026
HSER122

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE TAM H 1220
ChainResidue
HTYR32
HARG100
HGLU101
HSER102
HTYR103
HTYR104
HSER108
HHOH2312

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 H 1221
ChainResidue
AGLU140
ASER141
AHOH2247
AHOH2250
HGLU140
HSER141
HHOH2314

Functional Information from PROSITE/UniProt
site_idPS00254
Number of Residues26
DetailsINTERLEUKIN_6 Interleukin-6 / G-CSF / MGF signature. CfqsgfneetClvkiitGLleFevyL
ChainResidueDetails
CCYS73-LEU98

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
BTYR192-HIS198
ATYR201-HIS207

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039
ChainResidueDetails
CSER53
DSER53

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:1883960
ChainResidueDetails
CASN45
DASN45

222926

PDB entries from 2024-07-24

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