4CN7
Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to an idealized DR1 Response Element
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1205 |
| Chain | Residue |
| A | CYS135 |
| A | CYS138 |
| A | CYS152 |
| A | CYS155 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1206 |
| Chain | Residue |
| A | CYS171 |
| A | CYS177 |
| A | CYS187 |
| A | CYS190 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1211 |
| Chain | Residue |
| B | CYS138 |
| B | CYS152 |
| B | CYS155 |
| B | CYS135 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1212 |
| Chain | Residue |
| B | CYS171 |
| B | CYS177 |
| B | CYS187 |
| B | CYS190 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1208 |
| Chain | Residue |
| E | CYS135 |
| E | CYS138 |
| E | CYS152 |
| E | CYS155 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1209 |
| Chain | Residue |
| E | CYS171 |
| E | CYS177 |
| E | CYS187 |
| E | CYS190 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1211 |
| Chain | Residue |
| F | CYS135 |
| F | CYS138 |
| F | CYS152 |
| F | CYS155 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1212 |
| Chain | Residue |
| F | CYS171 |
| F | CYS177 |
| F | CYS187 |
| F | CYS190 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1207 |
| Chain | Residue |
| A | ILE179 |
| A | LYS194 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 1208 |
| Chain | Residue |
| A | VAL149 |
| A | TYR150 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL B 1213 |
| Chain | Residue |
| B | TYR169 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR |
| Chain | Residue | Details |
| A | CYS135-ARG161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS135-MET200 | |
| B | CYS135-MET200 | |
| E | CYS135-MET200 | |
| F | CYS135-MET200 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 176 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS135-CYS155 | |
| A | CYS171-CYS195 | |
| B | CYS135-CYS155 | |
| B | CYS171-CYS195 | |
| E | CYS135-CYS155 | |
| E | CYS171-CYS195 | |
| F | CYS135-CYS155 | |
| F | CYS171-CYS195 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4 |
| Chain | Residue | Details |
| A | CYS135 | |
| B | CYS138 | |
| B | CYS152 | |
| B | CYS155 | |
| B | CYS171 | |
| B | CYS177 | |
| B | CYS187 | |
| B | CYS190 | |
| E | CYS135 | |
| E | CYS138 | |
| E | CYS152 | |
| A | CYS138 | |
| E | CYS155 | |
| E | CYS171 | |
| E | CYS177 | |
| E | CYS187 | |
| E | CYS190 | |
| F | CYS135 | |
| F | CYS138 | |
| F | CYS152 | |
| F | CYS155 | |
| F | CYS171 | |
| A | CYS152 | |
| F | CYS177 | |
| F | CYS187 | |
| F | CYS190 | |
| A | CYS155 | |
| A | CYS171 | |
| A | CYS177 | |
| A | CYS187 | |
| A | CYS190 | |
| B | CYS135 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; by EP300 => ECO:0000269|PubMed:17761950 |
| Chain | Residue | Details |
| A | LYS145 | |
| B | LYS145 | |
| E | LYS145 | |
| F | LYS145 |
