4CN5

Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Nr1d1 Response Element

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008270	molecular_function	zinc ion binding
A	0043565	molecular_function	sequence-specific DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008270	molecular_function	zinc ion binding
B	0043565	molecular_function	sequence-specific DNA binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1210

Chain	Residue
A	CYS135
A	CYS138
A	CYS152
A	CYS155

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1211

Chain	Residue
A	CYS171
A	CYS177
A	CYS187
A	CYS190

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1210

Chain	Residue
B	CYS138
B	CYS152
B	CYS155
B	CYS135

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1211

Chain	Residue
B	CYS171
B	CYS177
B	CYS187
B	CYS190

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 1018

Chain	Residue
B	HOH2064
C	HOH2027
D	DT10
D	DG11
D	NO31019
D	HOH2027

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 1018

Chain	Residue
C	DT13
C	DC14
C	HOH2046
C	HOH2048

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 1019

Chain	Residue
C	DT6
C	DC7
C	HOH2016
C	HOH2018
C	HOH2064

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K C 1020

Chain	Residue
C	DA8
C	DG9
C	HOH2025
C	HOH2033
C	HOH2034

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NO3 D 1019

Chain	Residue
A	HOH2083
B	GLN206
B	ARG209
C	DG9
C	DA10
C	HOH2027
D	DT10
D	DG11
D	K1018

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1212

Chain	Residue
A	TYR169
A	TYR189

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 1213

Chain	Residue
A	LYS181
A	ARG182
A	LEU196
A	HOH2069
A	HOH2103

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL D 1020

Chain	Residue
A	GLN188
A	HOH2046
A	HOH2093
D	DC9

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1021

Chain	Residue
B	LYS160
C	DT12
C	DT13

---

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 1214

Chain	Residue
A	ARG172
A	CYS187

---

Functional Information from PROSITE/UniProt

site_id	PS00031
Number of Residues	27
Details	NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR

Chain	Residue	Details
A	CYS135-ARG161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	DNA binding: {"description":"Nuclear receptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	64
Details	Zinc finger: {"description":"NR C4-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00407","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Region: {"description":"Nuclear localization signal","evidences":[{"source":"PubMed","id":"12145331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10669605","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BY4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine; by EP300","evidences":[{"source":"PubMed","id":"17761950","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---