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4CN5

Crystal Structure of the Human Retinoid X Receptor DNA-Binding Domain Bound to the Human Nr1d1 Response Element

Functional Information from GO Data
ChainGOidnamespacecontents
A0003700molecular_functionDNA-binding transcription factor activity
A0006355biological_processregulation of DNA-templated transcription
A0008270molecular_functionzinc ion binding
A0043565molecular_functionsequence-specific DNA binding
B0003700molecular_functionDNA-binding transcription factor activity
B0006355biological_processregulation of DNA-templated transcription
B0008270molecular_functionzinc ion binding
B0043565molecular_functionsequence-specific DNA binding
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1210
ChainResidue
ACYS135
ACYS138
ACYS152
ACYS155

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1211
ChainResidue
ACYS171
ACYS177
ACYS187
ACYS190

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1210
ChainResidue
BCYS138
BCYS152
BCYS155
BCYS135

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 1211
ChainResidue
BCYS171
BCYS177
BCYS187
BCYS190

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K D 1018
ChainResidue
BHOH2064
CHOH2027
DDT10
DDG11
DNO31019
DHOH2027

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K C 1018
ChainResidue
CDT13
CDC14
CHOH2046
CHOH2048

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K C 1019
ChainResidue
CDT6
CDC7
CHOH2016
CHOH2018
CHOH2064

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K C 1020
ChainResidue
CDA8
CDG9
CHOH2025
CHOH2033
CHOH2034

site_idAC9
Number of Residues9
DetailsBINDING SITE FOR RESIDUE NO3 D 1019
ChainResidue
AHOH2083
BGLN206
BARG209
CDG9
CDA10
CHOH2027
DDT10
DDG11
DK1018

site_idBC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1212
ChainResidue
ATYR169
ATYR189

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL A 1213
ChainResidue
ALYS181
AARG182
ALEU196
AHOH2069
AHOH2103

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL D 1020
ChainResidue
AGLN188
AHOH2046
AHOH2093
DDC9

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 1021
ChainResidue
BLYS160
CDT12
CDT13

site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1214
ChainResidue
AARG172
ACYS187

Functional Information from PROSITE/UniProt
site_idPS00031
Number of Residues27
DetailsNUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CaiCg.Drssgk.HYgvysCegCkgFFkR
ChainResidueDetails
ACYS135-ARG161

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues130
DetailsDNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407
ChainResidueDetails
ACYS135-MET200
BCYS135-MET200

site_idSWS_FT_FI2
Number of Residues88
DetailsZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407
ChainResidueDetails
ACYS135-CYS155
ACYS171-CYS195
BCYS135-CYS155
BCYS171-CYS195

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000269|PubMed:10669605, ECO:0007744|PDB:1BY4
ChainResidueDetails
ACYS135
BCYS138
BCYS152
BCYS155
BCYS171
BCYS177
BCYS187
BCYS190
ACYS138
ACYS152
ACYS155
ACYS171
ACYS177
ACYS187
ACYS190
BCYS135

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by EP300 => ECO:0000269|PubMed:17761950
ChainResidueDetails
ALYS145
BLYS145

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PDB entries from 2024-10-30

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