4CLZ

Crystal structure of human soluble Adenylyl Cyclase with Inhibitor 4, 4'-Diisothiocyano-2,2'-stilbenedisulfonic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1469

Chain	Residue
A	LYS95
A	LEU166
A	VAL167
A	PHE336
A	MET337

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1470

Chain	Residue
A	TYR77
A	HIS78
A	ALA81
A	PHE130

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 1471

Chain	Residue
A	GLN9
A	SER80
A	HIS398
A	THR399
A	HOH2068
A	HOH2069
A	HOH2074

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1472

Chain	Residue
A	GLY397
A	THR399
A	HIS402
A	HOH2189

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1473

Chain	Residue
A	ASN2
A	LEU87
A	ILE88
A	PRO241
A	LEU248
A	LEU249

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1474

Chain	Residue
A	THR322
A	LEU325
A	LYS326
A	GLY330
A	GLN331
A	ILE332

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 1475

Chain	Residue
A	ARG106
A	GLU467
A	HOH2088
A	HOH2089
A	HOH2091
A	HOH2152
A	HOH2276

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 1476

Chain	Residue
A	ALA97
A	GLY98
A	PHE296
A	ASN333
A	LYS334
A	LEU345
A	THR405
A	VAL406

---

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG A 1477

Chain	Residue
A	GLN9
A	ASP10
A	TRP11
A	PRO12
A	ARG15
A	ASN279
A	HOH2190
A	HOH2277

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1478

Chain	Residue
A	HIS164
A	TYR268
A	ASN333
A	LYS334
A	VAL335
A	HOH2126

---

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 4DS A 1479

Chain	Residue
A	PHE8
A	ASP10
A	VAL14
A	ARG15
A	CME253
A	GLN276
A	ILE277
A	ASN279
A	GLN281
A	GLN283
A	THR399
A	VAL400
A	HOH2014
A	HOH2018
A	HOH2189
A	HOH2278
A	HOH2279

---

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 4DS A 1480

Chain	Residue
A	PHE45
A	LYS95
A	ALA97
A	LEU102
A	ARG176
A	ASN180
A	PHE336
A	PHE338
A	ASP339
A	ARG416
A	MET419
A	TYR420
A	HOH2222
A	HOH2246

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 4DS A 1481

Chain	Residue
A	HOH2067
A	HOH2281
A	PHE51
A	LYS57
A	TYR63
A	HIS78
A	PRO259
A	GLU260
A	MET263

---

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DMS A 1482

Chain	Residue
A	ILE24
A	GLY27
A	HIS28
A	PHE29
A	LEU261
A	SER264
A	HOH2175

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---