4CLP

Crystal structure of human soluble Adenylyl Cyclase complex with adenosine-3',5'-cyclic-monophosphate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0009190	biological_process	cyclic nucleotide biosynthetic process
A	0035556	biological_process	intracellular signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 1468

Chain	Residue
A	LYS95
A	HIS164
A	ASN333
A	LYS334
A	VAL335
A	GOL1472
A	HOH2077

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 1469

Chain	Residue
A	ILE332
A	HOH2104
A	HOH2171
A	THR322
A	GLN331

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 1470

Chain	Residue
A	LEU166
A	VAL167
A	MET337
A	HOH2207

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1471

Chain	Residue
A	ILE24
A	VAL25
A	TYR26
A	GLY27
A	HIS28
A	PHE29
A	LEU261
A	SER264
A	PEG1479
A	HOH2139

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 1472

Chain	Residue
A	HIS19
A	LYS95
A	PHE165
A	TYR268
A	LYS334
A	GLU403
A	ACT1468
A	HOH2013
A	HOH2077

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CMP A 1473

Chain	Residue
A	ARG199
A	ILE202
A	GLU203
A	ILE204
A	GLU205
A	SER206
A	SER323
A	LYS326
A	ILE327
A	HOH2112

---

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CMP A 1474

Chain	Residue
A	ALA97
A	GLY98
A	PHE336
A	PHE338
A	LEU345
A	THR405
A	VAL406
A	VAL411
A	ASN412
A	ARG416
A	HOH2045
A	HOH2174

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1475

Chain	Residue
A	LEU255
A	LYS256
A	ASP258
A	HOH2208

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1476

Chain	Residue
A	ARG290
A	GLY352
A	LYS354

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 1477

Chain	Residue
A	TYR432
A	SER435
A	LEU437

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1478

Chain	Residue
A	GLY243
A	PRO446
A	LYS447
A	HOH2209

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 1479

Chain	Residue
A	HIS28
A	ASP258
A	GLU260
A	LEU261
A	TYR440
A	GOL1471
A	HOH2026

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	125
Details	Domain: {"description":"Guanylate cyclase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4USW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00099","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CLL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4OYZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24567411","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"24616449","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25040695","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---