4CKC

Vaccinia virus capping enzyme complexed with SAH (monoclinic form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
A	0004484	molecular_function	mRNA guanylyltransferase activity
A	0004651	molecular_function	polynucleotide 5'-phosphatase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006353	biological_process	DNA-templated transcription termination
A	0006370	biological_process	7-methylguanosine mRNA capping
A	0006397	biological_process	mRNA processing
A	0008168	molecular_function	methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0016787	molecular_function	hydrolase activity
A	0032259	biological_process	methylation
A	0044423	cellular_component	virion component
A	0046872	molecular_function	metal ion binding
A	0050355	molecular_function	inorganic triphosphate phosphatase activity
A	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
A	0140818	molecular_function	mRNA 5'-triphosphate monophosphatase activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0005515	molecular_function	protein binding
B	0006353	biological_process	DNA-templated transcription termination
B	0006370	biological_process	7-methylguanosine mRNA capping
B	0006397	biological_process	mRNA processing
B	0044423	cellular_component	virion component
B	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
D	0000166	molecular_function	nucleotide binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004484	molecular_function	mRNA guanylyltransferase activity
D	0004651	molecular_function	polynucleotide 5'-phosphatase activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0006353	biological_process	DNA-templated transcription termination
D	0006370	biological_process	7-methylguanosine mRNA capping
D	0006397	biological_process	mRNA processing
D	0008168	molecular_function	methyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0016787	molecular_function	hydrolase activity
D	0032259	biological_process	methylation
D	0044423	cellular_component	virion component
D	0046872	molecular_function	metal ion binding
D	0050355	molecular_function	inorganic triphosphate phosphatase activity
D	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation
D	0140818	molecular_function	mRNA 5'-triphosphate monophosphatase activity
E	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
E	0005515	molecular_function	protein binding
E	0006353	biological_process	DNA-templated transcription termination
E	0006370	biological_process	7-methylguanosine mRNA capping
E	0006397	biological_process	mRNA processing
E	0044423	cellular_component	virion component
E	0106005	biological_process	RNA 5'-cap (guanine-N7)-methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 1845

Chain	Residue
A	ARG548
A	ALA603
A	ASP620
A	PRO621
A	ASP622
A	ARG655
A	GLN678
A	PHE679
A	TYR683
A	LEU549
A	ASN550
A	TYR555
A	PHE556
A	LYS573
A	ASP598
A	PHE599
A	GLY600

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site_id	AC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH D 1845

Chain	Residue
D	ARG548
D	LEU549
D	ASN550
D	TYR555
D	PHE556
D	LYS573
D	ASP598
D	PHE599
D	GLY600
D	ASP620
D	PRO621
D	ASP622
D	ARG655
D	GLN678
D	PHE679
D	TYR683

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"N6-GMP-lysine intermediate","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24607143","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	10
Details	Site: {"description":"Essential for RNA triphosphatase activity"}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	10
Details	Site: {"description":"mRNA cap binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00895","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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