4CID
Structural insights into the N-terminus of the EHD2 ATPase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005769 | cellular_component | early endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005901 | cellular_component | caveola |
| A | 0006897 | biological_process | endocytosis |
| A | 0010008 | cellular_component | endosome membrane |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0030139 | cellular_component | endocytic vesicle |
| A | 0030674 | molecular_function | protein-macromolecule adaptor activity |
| A | 0030866 | biological_process | cortical actin cytoskeleton organization |
| A | 0032456 | biological_process | endocytic recycling |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0055038 | cellular_component | recycling endosome membrane |
| A | 0060271 | biological_process | cilium assembly |
| A | 0072659 | biological_process | protein localization to plasma membrane |
| A | 0097320 | biological_process | plasma membrane tubulation |
| A | 1901741 | biological_process | positive regulation of myoblast fusion |
| A | 2001137 | biological_process | positive regulation of endocytic recycling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP A 1540 |
| Chain | Residue |
| A | GLN66 |
| A | GLY89 |
| A | PRO90 |
| A | PRO92 |
| A | THR93 |
| A | THR94 |
| A | GLY156 |
| A | ASN219 |
| A | LYS220 |
| A | PHE257 |
| A | TRP258 |
| A | TYR67 |
| A | MG1541 |
| A | SER68 |
| A | THR69 |
| A | GLY70 |
| A | LYS71 |
| A | THR72 |
| A | SER73 |
| A | VAL88 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1541 |
| Chain | Residue |
| A | THR72 |
| A | THR94 |
| A | ANP1540 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 701 |
| Chain | Residue |
| A | ASP494 |
| A | ASP496 |
| A | ASP498 |
| A | MSE500 |
| A | GLU505 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DVDRDGMLDdeEF |
| Chain | Residue | Details |
| A | ASP494-PHE506 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | Region: {"description":"G1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Region: {"description":"G2 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Region: {"description":"G3 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Region: {"description":"G4 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Region: {"description":"G5 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01055","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 20 |
| Details | Region: {"description":"Mediates membrane-binding","evidences":[{"source":"PubMed","id":"24508342","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17914359","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24508342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2QPT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CID","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24508342","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CID","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15345747","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19131326","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9NZN4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
