4CHB
Crystal structure of the human KLHL2 Kelch domain in complex with a WNK4 peptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1592 |
| Chain | Residue |
| A | ARG343 |
| A | ALA357 |
| A | GLY359 |
| A | VAL367 |
| A | THR369 |
| A | ASP371 |
| A | HOH2023 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1592 |
| Chain | Residue |
| A | HOH2035 |
| A | HOH2051 |
| A | HOH2159 |
| B | ARG368 |
| B | ARG389 |
| B | HOH2024 |
| B | HOH2134 |
| A | ARG368 |
| A | ARG389 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1593 |
| Chain | Residue |
| A | ARG368 |
| A | ARG389 |
| A | HOH2036 |
| A | HOH2159 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 1594 |
| Chain | Residue |
| A | PRO340 |
| A | SER341 |
| A | ARG343 |
| A | ASP371 |
| A | SER382 |
| A | HOH2038 |
| A | HOH2039 |
| B | ASN362 |
| B | SER364 |
| B | LEU365 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 12P A 1595 |
| Chain | Residue |
| A | LEU497 |
| A | ASP517 |
| A | ARG524 |
| A | VAL526 |
| A | TYR563 |
| B | ASN495 |
| B | ASP517 |
| B | ARG524 |
| B | VAL526 |
| B | TYR563 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1596 |
| Chain | Residue |
| A | SER341 |
| A | ARG343 |
| A | ASN362 |
| B | SER341 |
| B | ARG343 |
| B | ASN362 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1593 |
| Chain | Residue |
| B | ARG343 |
| B | ALA357 |
| B | GLY359 |
| B | VAL367 |
| B | THR369 |
| B | ASP371 |
| B | HOH2017 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1594 |
| Chain | Residue |
| A | ASN362 |
| A | SER364 |
| A | LEU365 |
| A | HOH2033 |
| B | PRO340 |
| B | SER341 |
| B | ARG343 |
| B | ASP371 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1595 |
| Chain | Residue |
| B | ARG368 |
| B | ARG389 |
| B | HOH2134 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO C 1567 |
| Chain | Residue |
| A | LEU365 |
| A | ARG366 |
| A | ARG389 |
| A | ASP409 |
| C | GLU557 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO D 1567 |
| Chain | Residue |
| B | LEU365 |
| B | ARG366 |
| B | ARG389 |
| B | ASP409 |
| B | GLY410 |
| D | GLU557 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 94 |
| Details | Repeat: {"description":"Kelch 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 6"} |
| Chain | Residue | Details |
