4CH8
High-salt crystal structure of a thrombin-GpIbalpha peptide complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0007596 | biological_process | blood coagulation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0007596 | biological_process | blood coagulation |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0006508 | biological_process | proteolysis |
| C | 0007596 | biological_process | blood coagulation |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0007596 | biological_process | blood coagulation |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0006508 | biological_process | proteolysis |
| E | 0007596 | biological_process | blood coagulation |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0005509 | molecular_function | calcium ion binding |
| F | 0006508 | biological_process | proteolysis |
| F | 0007596 | biological_process | blood coagulation |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0005576 | cellular_component | extracellular region |
| G | 0006508 | biological_process | proteolysis |
| G | 0007596 | biological_process | blood coagulation |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005509 | molecular_function | calcium ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 1578 |
| Chain | Residue |
| B | ARG553 |
| B | LYS556 |
| B | HOH2089 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1580 |
| Chain | Residue |
| B | HOH2006 |
| B | GLY330 |
| B | MET331 |
| B | SER332 |
| B | PRO333 |
| B | LYS385 |
| B | TYR434 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA D 1580 |
| Chain | Residue |
| D | ARG553 |
| D | LYS556 |
| D | HOH2085 |
| D | HOH2099 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA F 1578 |
| Chain | Residue |
| F | ARG553 |
| F | LYS556 |
| F | HOH2071 |
| F | HOH2072 |
| F | HOH2089 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL F 1580 |
| Chain | Residue |
| F | LEU450 |
| F | VAL488 |
| F | ARG490 |
| F | CYS493 |
| F | PHE506 |
| F | CYS507 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA H 1580 |
| Chain | Residue |
| H | ARG553 |
| H | LYS556 |
| H | HOH2073 |
| H | HOH2084 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | Binding site for Ligand 0G6 B1579 bound to SER B 525 |
| Chain | Residue |
| B | HIS363 |
| B | GLU414 |
| B | ASP519 |
| B | ALA520 |
| B | GLY523 |
| B | SER525 |
| B | SER546 |
| B | TRP547 |
| B | GLY548 |
| B | GLY550 |
| B | GLY558 |
| B | HOH2015 |
| B | HOH2080 |
| B | HOH2081 |
| B | HOH2082 |
| B | HOH2086 |
| site_id | AC8 |
| Number of Residues | 16 |
| Details | Binding site for Ligand 0G6 D1581 bound to SER D 525 |
| Chain | Residue |
| D | HIS363 |
| D | TYR367 |
| D | LEU416 |
| D | ASP519 |
| D | ALA520 |
| D | GLY523 |
| D | ASP524 |
| D | SER525 |
| D | SER546 |
| D | TRP547 |
| D | GLY548 |
| D | GLY550 |
| D | HOH2087 |
| D | HOH2088 |
| D | HOH2090 |
| D | HOH2095 |
| site_id | AC9 |
| Number of Residues | 19 |
| Details | Binding site for Ligand 0G6 F1579 bound to SER F 525 |
| Chain | Residue |
| F | HIS363 |
| F | TYR367 |
| F | LEU416 |
| F | ASP519 |
| F | ALA520 |
| F | GLY523 |
| F | SER525 |
| F | SER546 |
| F | TRP547 |
| F | GLY548 |
| F | GLY550 |
| F | GLY558 |
| F | HOH2079 |
| F | HOH2080 |
| F | HOH2081 |
| F | HOH2082 |
| F | HOH2085 |
| F | HOH2093 |
| F | HOH2094 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | Binding site for Ligand 0G6 H1581 bound to SER H 525 |
| Chain | Residue |
| H | HIS363 |
| H | TYR367 |
| H | LEU416 |
| H | ASP519 |
| H | ALA520 |
| H | GLY523 |
| H | SER525 |
| H | SER546 |
| H | TRP547 |
| H | GLY548 |
| H | GLY550 |
| H | GLY558 |
| H | HOH2076 |
| H | HOH2077 |
| H | HOH2081 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| B | LEU359-CYS364 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV |
| Chain | Residue | Details |
| B | ASP519-VAL530 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 254 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
