4CGY

Crystal structure of the human topoisomerase III alpha-RMI1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003916	molecular_function	DNA topoisomerase activity
A	0003917	molecular_function	DNA topoisomerase type I (single strand cut, ATP-independent) activity
A	0005694	cellular_component	chromosome
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 1640

Chain	Residue
A	GLU41
A	HOH2003
A	HOH2004
A	HOH2005
A	HOH2006
A	HOH2010

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Functional Information from PROSITE/UniProt

site_id	PS00396
Number of Residues	15
Details	TOPO_IA_1 Topoisomerase (Topo) IA-type active site signature. EkLYTqgy.........ISYpRTE

Chain	Residue	Details
A	GLU352-GLU366

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378

Chain	Residue	Details
B	MET1

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: O-(5'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01383

Chain	Residue	Details
A	TYR362

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