4CG7
Cryo-EM of the Sec61-complex bound to the idle 80S ribosome
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005048 | molecular_function | signal sequence binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005784 | cellular_component | Sec61 translocon complex |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006613 | biological_process | cotranslational protein targeting to membrane |
| A | 0006616 | biological_process | SRP-dependent cotranslational protein targeting to membrane, translocation |
| A | 0008320 | molecular_function | protein transmembrane transporter activity |
| A | 0015031 | biological_process | protein transport |
| A | 0016020 | cellular_component | membrane |
| A | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| A | 0039019 | biological_process | pronephric nephron development |
| A | 0043022 | molecular_function | ribosome binding |
| A | 0045047 | biological_process | protein targeting to ER |
| A | 0045048 | biological_process | protein insertion into ER membrane |
| B | 0005543 | molecular_function | phospholipid binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006605 | biological_process | protein targeting |
| B | 0006886 | biological_process | intracellular protein transport |
| B | 0008320 | molecular_function | protein transmembrane transporter activity |
| B | 0015031 | biological_process | protein transport |
| B | 0016020 | cellular_component | membrane |
| B | 0022406 | biological_process | membrane docking |
| B | 0031204 | biological_process | post-translational protein targeting to membrane, translocation |
| B | 0043022 | molecular_function | ribosome binding |
| B | 0045047 | biological_process | protein targeting to ER |
| B | 0071261 | cellular_component | Ssh1 translocon complex |
| C | 0005784 | cellular_component | Sec61 translocon complex |
| C | 0006886 | biological_process | intracellular protein transport |
Functional Information from PROSITE/UniProt
| site_id | PS00755 |
| Number of Residues | 20 |
| Details | SECY_1 Protein secY signature 1. TLMeLGIsPIVtSGLIMQLL |
| Chain | Residue | Details |
| A | THR75-LEU94 |
| site_id | PS00756 |
| Number of Residues | 19 |
| Details | SECY_2 Protein secY signature 2. LLdElLQkgyGLGSGiSLF |
| Chain | Residue | Details |
| A | LEU164-PHE182 |
| site_id | PS01067 |
| Number of Residues | 29 |
| Details | SECE_SEC61G Protein secE/sec61-gamma signature. FvKDsIrlVkRctKPdrkEfqkiaMATAI |
| Chain | Residue | Details |
| B | PHE14-ILE42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 223 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"36261528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TUT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 151 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"36261528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TUT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 102 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"36261528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TUT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"36261528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7TM3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7TUT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P60059","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
