4CFR
Ca-bound S100A4 C3S, C81S, C86S and F45W mutant complexed with non- muscle myosin IIA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001837 | biological_process | epithelial to mesenchymal transition |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003779 | molecular_function | actin binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0042056 | molecular_function | chemoattractant activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0050786 | molecular_function | RAGE receptor binding |
| A | 0050918 | biological_process | positive chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001837 | biological_process | epithelial to mesenchymal transition |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003779 | molecular_function | actin binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0031012 | cellular_component | extracellular matrix |
| B | 0042056 | molecular_function | chemoattractant activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0048306 | molecular_function | calcium-dependent protein binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0050786 | molecular_function | RAGE receptor binding |
| B | 0050918 | biological_process | positive chemotaxis |
| B | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1096 |
| Chain | Residue |
| A | SER20 |
| A | GLU23 |
| A | ASP25 |
| A | LYS28 |
| A | GLU33 |
| A | HOH2046 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1097 |
| Chain | Residue |
| A | GLU69 |
| A | GLU74 |
| A | HOH2105 |
| A | ASP63 |
| A | ASN65 |
| A | ASP67 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1101 |
| Chain | Residue |
| B | SER20 |
| B | GLU23 |
| B | ASP25 |
| B | LYS28 |
| B | GLU33 |
| B | HOH2031 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1102 |
| Chain | Residue |
| B | ASP63 |
| B | ASN65 |
| B | ASP67 |
| B | GLU69 |
| B | GLU74 |
| B | HOH2036 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 70 |
| Details | Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P35466","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q61879","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
