4CEI
Crystal structure of ADPNP-bound AddAB with a forked DNA substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000724 | biological_process | double-strand break repair via homologous recombination |
| A | 0000725 | biological_process | recombinational repair |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003678 | molecular_function | DNA helicase activity |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0004386 | molecular_function | helicase activity |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004527 | molecular_function | exonuclease activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006302 | biological_process | double-strand break repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0033202 | cellular_component | DNA helicase complex |
| A | 0043138 | molecular_function | 3'-5' DNA helicase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000724 | biological_process | double-strand break repair via homologous recombination |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003690 | molecular_function | double-stranded DNA binding |
| B | 0004386 | molecular_function | helicase activity |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0004527 | molecular_function | exonuclease activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006281 | biological_process | DNA repair |
| B | 0006310 | biological_process | DNA recombination |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008409 | molecular_function | 5'-3' exonuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016788 | molecular_function | hydrolase activity, acting on ester bonds |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051536 | molecular_function | iron-sulfur cluster binding |
| B | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE ANP A 2233 |
| Chain | Residue |
| A | THR10 |
| A | ARG76 |
| A | GLU408 |
| A | GLN441 |
| A | PHE478 |
| A | ARG479 |
| A | LYS573 |
| A | GLY798 |
| A | GLU800 |
| A | ARG873 |
| A | HOH2001 |
| A | GLN15 |
| A | HOH2002 |
| A | HOH2004 |
| A | MG2234 |
| A | ALA32 |
| A | GLY33 |
| A | SER34 |
| A | GLY35 |
| A | LYS36 |
| A | THR37 |
| A | ALA38 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2234 |
| Chain | Residue |
| A | THR37 |
| A | HOH2001 |
| A | HOH2002 |
| A | HOH2003 |
| A | ANP2233 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SF4 B 2160 |
| Chain | Residue |
| B | CYS801 |
| B | PRO1112 |
| B | CYS1121 |
| B | CYS1124 |
| B | CYS1130 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE ANP B 2161 |
| Chain | Residue |
| B | SER10 |
| B | GLY11 |
| B | GLY13 |
| B | LYS14 |
| B | THR15 |
| B | LYS16 |
| B | THR236 |
| B | GLU282 |
| B | ARG283 |
| B | GLY600 |
| B | MET656 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2004 |
| B | MG2162 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 2162 |
| Chain | Residue |
| B | THR15 |
| B | ASP208 |
| B | HOH2001 |
| B | HOH2002 |
| B | HOH2003 |
| B | ANP2161 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 472 |
| Details | Domain: {"description":"UvrD-like helicase ATP-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"4CEI","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4CEJ","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24670664","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4CEI","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"4CEJ","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24670664","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"4CEI","evidenceCode":"ECO:0000312"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 305 |
| Details | Domain: {"description":"UvrD-like helicase C-terminal","evidences":[{"source":"HAMAP-Rule","id":"MF_01452","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01452","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"22307084","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24670664","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3U44","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CEH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CEI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CEJ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
