Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4CDR

Human O-GlcNAc transferase in complex with a bisubstrate inhibitor, Goblin1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity
B	0006493	biological_process	protein O-linked glycosylation
B	0016757	molecular_function	glycosyltransferase activity
C	0006493	biological_process	protein O-linked glycosylation
C	0016757	molecular_function	glycosyltransferase activity
D	0006493	biological_process	protein O-linked glycosylation
D	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2029

Chain	Residue
A	ASN321
A	ASN325
A	ALA352
A	ASN356

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 E 1009

Chain	Residue
A	LYS430
A	HIS461
A	HIS499
E	THR7
E	ALA8

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2030

Chain	Residue
A	PHE602
A	ILE603
A	ASP604
A	ARG617

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 2031

Chain	Residue
A	HIS601

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 2032

Chain	Residue
A	LYS685
A	HIS1025
C	ASN888

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2033

Chain	Residue
A	ARG491
A	LEU492

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2034

Chain	Residue
A	ARG857
A	VAL971

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2035

Chain	Residue
A	ASN962
A	ARG963

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2036

Chain	Residue
A	ARG410
A	GLN413
B	ARG410
D	ARG410

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 2029

Chain	Residue
B	ASN321
B	ASN325
B	ALA352
B	ASN356

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 F 1009

Chain	Residue
B	LYS430
B	HIS461
B	HIS499
F	THR7
F	ALA8

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 2030

Chain	Residue
B	PHE602
B	ILE603
B	ASP604
B	ARG617

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 2031

Chain	Residue
B	HIS601
C	LYS342

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 2032

Chain	Residue
A	ASN888
B	LYS685
B	HIS1025

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 2033

Chain	Residue
B	ARG491
B	LEU492

site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 2034

Chain	Residue
B	ARG857

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 2035

Chain	Residue
B	ASN962
B	ARG963

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2029

Chain	Residue
C	ASN321
C	ASN325
C	ALA352
C	ASN356

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 2030

Chain	Residue
C	LYS430
C	HIS461
C	HIS499
G	THR7
G	ALA8

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 2031

Chain	Residue
C	ILE603
C	ASP604
C	ARG617

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 2032

Chain	Residue
C	HIS601

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 2033

Chain	Residue
C	ARG491
C	LEU492

site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 2034

Chain	Residue
C	ASN962
C	ARG963

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 2029

Chain	Residue
D	ASN321
D	ASN325
D	ALA352
D	ASN356

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 H 1009

Chain	Residue
D	HIS461
D	HIS499
H	THR7
H	ALA8

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 2030

Chain	Residue
D	PHE602
D	ILE603
D	ASP604
D	ARG617

site_id	CC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 D 2031

Chain	Residue
D	HIS601

site_id	DC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 2032

Chain	Residue
D	LYS685
D	HIS1025

site_id	DC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 2033

Chain	Residue
D	ARG491
D	LEU492

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 2034

Chain	Residue
D	ARG857
D	VAL971

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 2035

Chain	Residue
D	ASN962
D	ARG963

site_id	DC5
Number of Residues	21
Details	BINDING SITE FOR CHAIN H AND UDP H1001

Chain	Residue
A	ALA896
A	LYS898
A	HIS901
A	ARG904
A	HIS920
A	THR921
A	THR922
A	ASP925
B	ASP318
E	SO41009
A	HIS496
A	HIS498
A	HIS499
A	ASN557
A	PRO559
A	TYR632
A	THR633
A	LYS634
A	GLN839
A	LYS842
A	VAL895

site_id	DC6
Number of Residues	19
Details	BINDING SITE FOR CHAIN F AND UDP F1001

Chain	Residue
B	ASN557
B	PRO559
B	TYR632
B	THR633
B	LYS634
B	GLN839
B	LYS842
B	LEU866
B	VAL895
B	ALA896
B	LYS898
B	HIS901
B	ARG904
B	HIS920
B	THR921
B	THR922
B	ASP925
D	PRO314
F	SO41009

site_id	DC7
Number of Residues	19
Details	BINDING SITE FOR CHAIN G AND UDP G1001

Chain	Residue
C	HIS499
C	ASN557
C	PRO559
C	TYR632
C	THR633
C	LYS634
C	GLN839
C	LYS842
C	LEU866
C	VAL895
C	ALA896
C	LYS898
C	HIS901
C	ARG904
C	HIS920
C	THR921
C	THR922
C	ASP925
C	SO42030

site_id	DC8
Number of Residues	20
Details	BINDING SITE FOR CHAIN H AND UDP H1001

Chain	Residue
A	PRO314
D	HIS496
D	ASN557
D	PRO559
D	TYR632
D	THR633
D	LYS634
D	GLN839
D	LYS842
D	LEU866
D	VAL895
D	ALA896
D	LYS898
D	HIS901
D	ARG904
D	HIS920
D	THR921
D	THR922
D	ASP925
H	SO41009

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000305\|PubMed:21240259, ECO:0000305\|PubMed:26678539

Chain	Residue	Details
A	HIS498
B	HIS498
C	HIS498
D	HIS498

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:23103939, ECO:0007744\|PDB:4GYW

Chain	Residue	Details
A	GLN839
B	HIS901
B	HIS920
B	ASP925
C	GLN839
C	LYS842
C	ALA896
C	HIS901
C	HIS920
C	ASP925
D	GLN839
A	LYS842
D	LYS842
D	ALA896
D	HIS901
D	HIS920
D	ASP925
A	ALA896
A	HIS901
A	HIS920
A	ASP925
B	GLN839
B	LYS842
B	ALA896

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269\|PubMed:24563466, ECO:0000269\|PubMed:37541260

Chain	Residue	Details
A	THR444
B	THR444
C	THR444
D	THR444

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P56558

Chain	Residue	Details
A	TYR979
B	TYR979
C	TYR979
D	TYR979

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269\|PubMed:27713473

Chain	Residue	Details
A	SER389
B	SER389
C	SER389
D	SER389

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)