4CCZ
Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0008705 | molecular_function | methionine synthase activity |
| A | 0009086 | biological_process | obsolete methionine biosynthetic process |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0042558 | biological_process | pteridine-containing compound metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE THG A 1652 |
| Chain | Residue |
| A | GLU376 |
| A | SER578 |
| A | ASN579 |
| A | PHE582 |
| A | ARG585 |
| A | ARG591 |
| A | ILE611 |
| A | ASN379 |
| A | GLY382 |
| A | ARG384 |
| A | ASP449 |
| A | ASN470 |
| A | MET498 |
| A | ASP537 |
| A | GLY576 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 261 |
| Details | Domain: {"description":"Pterin-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00334","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00333","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"OCT-2013","submissionDatabase":"PDB data bank","title":"Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains.","authors":["Vollmar M.","Kiyani W.","Krojer T.","Goubin S.","Burgess-Brown N.","Von Delft F.","Oppermann U.","Edwards A.","Arrowsmith C.","Bountra C.","Yue W.W."]}},{"source":"PDB","id":"4CCZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
