4CC0

Notch ligand, Jagged-1, contains an N-terminal C2 domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
A	0007154	biological_process	cell communication
A	0007219	biological_process	Notch signaling pathway
A	0007275	biological_process	multicellular organism development
A	0016020	cellular_component	membrane
B	0005509	molecular_function	calcium ion binding
B	0007154	biological_process	cell communication
B	0007219	biological_process	Notch signaling pathway
B	0007275	biological_process	multicellular organism development
B	0016020	cellular_component	membrane

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CrCqyGwqGLyC

Chain	Residue	Details
A	CYS251-CYS262
A	CYS282-CYS293
A	CYS322-CYS333

---

site_id	PS01186
Number of Residues	15
Details	EGF_2 EGF-like domain signature 2. CrCqyGWqglycdk.C

Chain	Residue	Details
A	CYS251-CYS265
A	CYS322-CYS333

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	88
Details	Domain: {"description":"DSL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00377","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	66
Details	Domain: {"description":"EGF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	60
Details	Domain: {"description":"EGF-like 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	38
Details	Domain: {"description":"EGF-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	16
Details	Region: {"description":"Important for interaction with NOTCH1","evidences":[{"source":"PubMed","id":"18660822","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---