4CBW
Crystal structure of Plasmodium berghei actin I with D-loop from muscle actin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| G | 0051015 | molecular_function | actin filament binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1377 |
| Chain | Residue |
| A | ATP1379 |
| A | HOH2003 |
| A | HOH2005 |
| A | HOH2006 |
| A | HOH2015 |
| A | HOH2022 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA G 1150 |
| Chain | Residue |
| G | ASP109 |
| G | GLY114 |
| G | ALA116 |
| A | GLU168 |
| A | HOH2024 |
| A | HOH2025 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA G 1151 |
| Chain | Residue |
| G | GLY65 |
| G | ASP66 |
| G | GLU97 |
| G | VAL145 |
| G | HOH2006 |
| G | HOH2015 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE DIO A 1378 |
| Chain | Residue |
| A | TYR144 |
| A | TYR170 |
| A | PHE376 |
| G | GLN107 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ATP A 1379 |
| Chain | Residue |
| A | GLY14 |
| A | SER15 |
| A | GLY16 |
| A | ASN17 |
| A | LYS19 |
| A | GLY157 |
| A | ASP158 |
| A | GLY159 |
| A | VAL160 |
| A | GLY183 |
| A | LYS214 |
| A | GLU215 |
| A | GLY303 |
| A | THR304 |
| A | MET306 |
| A | CA1377 |
| A | HOH2006 |
| A | HOH2007 |
| A | HOH2021 |
| A | HOH2022 |
Functional Information from PROSITE/UniProt
| site_id | PS00406 |
| Number of Residues | 11 |
| Details | ACTINS_1 Actins signature 1. YVGDEAQs.KRG |
| Chain | Residue | Details |
| A | TYR54-GLY64 |
| site_id | PS00432 |
| Number of Residues | 9 |
| Details | ACTINS_2 Actins signature 2. WITKeEYDE |
| Chain | Residue | Details |
| A | TRP357-GLU365 |
| site_id | PS01132 |
| Number of Residues | 13 |
| Details | ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPkgNR |
| Chain | Residue | Details |
| A | LEU105-ARG117 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Region: {"description":"Interaction with alpha-actinin","evidences":[{"source":"UniProtKB","id":"P68135","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P68134","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-malonyllysine","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P68138","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P68133","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBW","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 81 |
| Details | Repeat: {"description":"Gelsolin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Region: {"description":"Actin-actin interfilament contact point"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28695858","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MVV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24743229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31199804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4CBU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CBX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4F","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4J","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4K","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6I4M","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P06396","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
