Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019430 | biological_process | removal of superoxide radicals |
| A | 0045454 | biological_process | cell redox homeostasis |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019430 | biological_process | removal of superoxide radicals |
| B | 0045454 | biological_process | cell redox homeostasis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP A 1315 |
| Chain | Residue |
| A | GLY160 |
| A | ALA245 |
| A | ILE246 |
| A | SO41316 |
| A | FAD1320 |
| A | HOH2125 |
| A | HOH2126 |
| A | HOH2128 |
| A | HOH2131 |
| A | HOH2134 |
| A | HOH2168 |
| A | GLY161 |
| A | HOH2217 |
| A | HOH2218 |
| A | HOH2219 |
| A | HOH2220 |
| A | HOH2222 |
| A | ASP162 |
| A | ALA163 |
| A | GLU166 |
| A | HIS182 |
| A | ARG183 |
| A | ARG184 |
| A | ARG188 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP B 1315 |
| Chain | Residue |
| A | SO41316 |
| A | HOH2133 |
| B | LYS122 |
| B | GLY160 |
| B | GLY161 |
| B | ASP162 |
| B | ALA163 |
| B | HIS182 |
| B | ARG183 |
| B | ARG184 |
| B | ARG188 |
| B | ALA245 |
| B | ILE246 |
| B | HIS248 |
| B | TYR290 |
| B | ARG291 |
| B | GLN292 |
| B | HOH2099 |
| B | HOH2100 |
| B | HOH2107 |
| B | HOH2108 |
| B | HOH2110 |
| B | HOH2147 |
| B | HOH2192 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1316 |
| Chain | Residue |
| A | ARG183 |
| A | NDP1315 |
| B | ARG183 |
| B | NDP1315 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1316 |
| Chain | Residue |
| B | LEU268 |
| B | LYS273 |
| B | THR274 |
| B | SER275 |
| B | HOH2159 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1317 |
| Chain | Residue |
| B | GLY128 |
| B | GLU129 |
| B | ASP130 |
| B | LYS131 |
| B | HOH2082 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1317 |
| Chain | Residue |
| A | PRO127 |
| A | GLY128 |
| A | GLU129 |
| A | ASP130 |
| A | LYS131 |
| A | HOH2107 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1318 |
| Chain | Residue |
| A | LEU268 |
| A | THR269 |
| A | GLU270 |
| A | THR274 |
| A | SER275 |
| A | HOH2182 |
| A | HOH2194 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU A 1319 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE AU B 1318 |
| site_id | BC1 |
| Number of Residues | 42 |
| Details | BINDING SITE FOR RESIDUE FAD A 1320 |
| Chain | Residue |
| A | THR117 |
| A | GLY118 |
| A | ALA119 |
| A | HIS248 |
| A | GLY283 |
| A | ASP284 |
| A | ARG291 |
| A | GLN292 |
| A | ALA293 |
| A | ALA296 |
| A | NDP1315 |
| A | HOH2009 |
| A | HOH2022 |
| A | HOH2037 |
| A | HOH2042 |
| A | HOH2044 |
| A | HOH2098 |
| A | HOH2099 |
| A | HOH2224 |
| B | TYR22 |
| A | ILE10 |
| A | GLY11 |
| A | SER12 |
| A | GLY13 |
| A | PRO14 |
| A | ALA15 |
| A | TYR33 |
| A | GLU34 |
| A | GLY35 |
| A | ALA38 |
| A | VAL41 |
| A | ALA42 |
| A | ALA43 |
| A | GLY45 |
| A | GLN46 |
| A | LEU47 |
| A | THR50 |
| A | ILE53 |
| A | ASN55 |
| A | THR87 |
| A | ILE88 |
| A | ALA116 |
| site_id | BC2 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD B 1321 |
| Chain | Residue |
| A | TYR22 |
| A | HOH2015 |
| B | ILE10 |
| B | GLY11 |
| B | SER12 |
| B | GLY13 |
| B | PRO14 |
| B | ALA15 |
| B | TYR33 |
| B | GLU34 |
| B | GLY35 |
| B | ALA38 |
| B | VAL41 |
| B | ALA42 |
| B | ALA43 |
| B | GLY45 |
| B | GLN46 |
| B | LEU47 |
| B | THR50 |
| B | ILE53 |
| B | ASN55 |
| B | ILE88 |
| B | THR117 |
| B | GLY118 |
| B | ALA119 |
| B | GLY283 |
| B | ASP284 |
| B | ARG291 |
| B | GLN292 |
| B | ALA293 |
| B | ALA296 |
| B | HOH2013 |
| B | HOH2025 |
| B | HOH2034 |
| B | HOH2039 |
| B | HOH2040 |
| B | HOH2074 |
| B | HOH2075 |
| B | HOH2193 |
Functional Information from PROSITE/UniProt
| site_id | PS00573 |
| Number of Residues | 23 |
| Details | PYRIDINE_REDOX_2 Pyridine nucleotide-disulphide oxidoreductases class-II active site. CaiCDGavpiFrnkvLmVVGGGD |
| Chain | Residue | Details |
| A | CYS140-ASP162 | |
