Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4CBJ

The c-ring ion binding site of the ATP synthase from Bacillus pseudofirmus OF4 is adapted to alkaliphilic cell physiology

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0008289	molecular_function	lipid binding
A	0015078	molecular_function	proton transmembrane transporter activity
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
A	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0005886	cellular_component	plasma membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0008289	molecular_function	lipid binding
B	0015078	molecular_function	proton transmembrane transporter activity
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0005886	cellular_component	plasma membrane
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0008289	molecular_function	lipid binding
C	0015078	molecular_function	proton transmembrane transporter activity
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
C	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0005886	cellular_component	plasma membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0008289	molecular_function	lipid binding
D	0015078	molecular_function	proton transmembrane transporter activity
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0005886	cellular_component	plasma membrane
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0008289	molecular_function	lipid binding
E	0015078	molecular_function	proton transmembrane transporter activity
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0008289	molecular_function	lipid binding
F	0015078	molecular_function	proton transmembrane transporter activity
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
F	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0008289	molecular_function	lipid binding
G	0015078	molecular_function	proton transmembrane transporter activity
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
G	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0005886	cellular_component	plasma membrane
H	0006754	biological_process	ATP biosynthetic process
H	0006811	biological_process	monoatomic ion transport
H	0008289	molecular_function	lipid binding
H	0015078	molecular_function	proton transmembrane transporter activity
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016020	cellular_component	membrane
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005886	cellular_component	plasma membrane
I	0006754	biological_process	ATP biosynthetic process
I	0006811	biological_process	monoatomic ion transport
I	0008289	molecular_function	lipid binding
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016020	cellular_component	membrane
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
I	1902600	biological_process	proton transmembrane transport
J	0005886	cellular_component	plasma membrane
J	0006754	biological_process	ATP biosynthetic process
J	0006811	biological_process	monoatomic ion transport
J	0008289	molecular_function	lipid binding
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016020	cellular_component	membrane
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
J	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	1902600	biological_process	proton transmembrane transport
K	0005886	cellular_component	plasma membrane
K	0006754	biological_process	ATP biosynthetic process
K	0006811	biological_process	monoatomic ion transport
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0005886	cellular_component	plasma membrane
L	0006754	biological_process	ATP biosynthetic process
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0005886	cellular_component	plasma membrane
M	0006754	biological_process	ATP biosynthetic process
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DPV A 200

Chain	Residue
A	LYS26
A	GLU30
B	LYS26
B	GLU30
B	DPV200
M	DPV200

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE TAM A 1070

Chain	Residue
A	PRO36
A	HOH2002
M	ARG34
M	GLN35
A	THR33
A	ARG34
A	GLN35

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DPV B 200

Chain	Residue
A	DPV200
B	LYS26
C	LYS26
C	DPV200

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DPV C 200

Chain	Residue
B	ILE23
B	DPV200
C	LYS26
C	GLU30
D	LYS26
D	GLU30
D	DPV200

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DPV D 200

Chain	Residue
C	ILE23
C	DPV200
E	DPV200

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE TAM D 1070

Chain	Residue
C	GLN35
D	ARG34
D	GLN35

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DPV E 200

Chain	Residue
D	ILE23
D	DPV200
E	LYS26
F	DPV200

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DPV F 200

Chain	Residue
E	DPV200
F	ILE19
F	ILE23
F	LYS26
F	GLU30
G	LYS26
G	DPV200

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DPV G 200

Chain	Residue
F	ILE23
F	DPV200
G	LYS26
G	GLU30
H	LYS26
H	DPV200

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DPV H 200

Chain	Residue
G	DPV200
H	LYS26
I	DPV200

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DPV I 200

Chain	Residue
H	DPV200
I	ILE23
I	LYS26
J	LYS26
J	DPV200

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DPV J 200

Chain	Residue
I	ILE23
I	DPV200
J	ILE23
J	LYS26
K	LYS26
K	GLU30
K	DPV200

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DPV K 200

Chain	Residue
J	DPV200
K	ILE23
K	LYS26
L	LYS26
L	DPV200

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE TAM K 1070

Chain	Residue
K	ARG34
K	GLN35
K	PRO36
K	GLU37

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DPV L 200

Chain	Residue
K	ILE23
K	DPV200
M	LYS26
M	DPV200

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE DPV M 200

Chain	Residue
A	LYS26
A	DPV200
L	DPV200
M	ILE23
M	LYS26

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LMT J 1070

Chain	Residue
B	ARG39
B	GLN43
J	PHE3
J	LEU68
J	PHE69

Functional Information from PROSITE/UniProt

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. TRQPelrgtLqTlmFIgvaLaE

Chain	Residue	Details
A	THR33-GLU54
C	THR33-GLU54

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255\|HAMAP-Rule:MF_01396

Chain	Residue	Details
C	GLY5-VAL25
G	PHE47-ILE67
H	GLY5-VAL25
H	PHE47-ILE67
M	GLY5-VAL25
M	PHE47-ILE67
C	PHE47-ILE67
D	GLY5-VAL25
D	PHE47-ILE67
E	GLY5-VAL25
E	PHE47-ILE67
F	GLY5-VAL25
F	PHE47-ILE67
G	GLY5-VAL25

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Reversibly protonated during proton transport => ECO:0000255\|HAMAP-Rule:MF_01396

Chain	Residue	Details
C	GLU54
D	GLU54
E	GLU54
F	GLU54
G	GLU54
H	GLU54
M	GLU54

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)