4CAV

Crystal structure of Aspergillus fumigatus N-myristoyl transferase in complex with myristoyl CoA and a benzofuran ligand R0-09-4879

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004379	molecular_function	glycylpeptide N-tetradecanoyltransferase activity
A	0006499	biological_process	N-terminal protein myristoylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 1493

Chain	Residue
A	2XQ1494

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site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE 2XQ A 1494

Chain	Residue
A	PHE278
A	LEU376
A	VAL389
A	TYR393
A	VAL432
A	ASN434
A	ALA435
A	LEU492
A	CL1493
A	TYR147
A	PHE155
A	PHE157
A	TYR159
A	PHE214
A	TYR264
A	HIS265
A	LEU273

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site_id	AC3
Number of Residues	37
Details	BINDING SITE FOR RESIDUE MYA A 1495

Chain	Residue
A	TYR147
A	VAL148
A	ASN213
A	PHE214
A	LEU215
A	CYS216
A	ILE217
A	ARG222
A	SER223
A	LYS224
A	ARG225
A	LEU226
A	THR227
A	ILE231
A	THR235
A	CYS238
A	ILE243
A	TYR244
A	GLN245
A	ALA246
A	TYR248
A	THR249
A	VAL252
A	LEU254
A	TYR462
A	HOH2176
A	HOH2177
A	HOH2178
A	HOH2265
A	HOH2403
A	HOH2405
A	HOH2406
A	HOH2407
A	HOH2408
A	HOH2409
A	HOH2410
A	HOH2411

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Functional Information from PROSITE/UniProt

site_id	PS00975
Number of Residues	9
Details	NMT_1 Myristoyl-CoA:protein N-myristoyltransferase signature 1. EINFLCiHK

Chain	Residue	Details
A	GLU211-LYS219

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site_id	PS00976
Number of Residues	7
Details	NMT_2 Myristoyl-CoA:protein N-myristoyltransferase signature 2. KFGaGDG

Chain	Residue	Details
A	LYS449-GLY455

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor; via carboxylate => ECO:0000250

Chain	Residue	Details
A	LEU492

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P14743

Chain	Residue	Details
A	LEU215
A	SER223

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