4CA1
Crystal structure of Siah1 at 1.58 A resolution.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0007275 | biological_process | multicellular organism development |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| B | 0007275 | biological_process | multicellular organism development |
| B | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 283 |
| Chain | Residue |
| A | CYS98 |
| A | CYS105 |
| A | HIS117 |
| A | CYS121 |
| A | HOH2010 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 284 |
| Chain | Residue |
| A | CYS128 |
| A | CYS135 |
| A | HIS147 |
| A | HIS152 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 283 |
| Chain | Residue |
| B | CYS98 |
| B | CYS105 |
| B | HIS117 |
| B | CYS121 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 284 |
| Chain | Residue |
| B | CYS128 |
| B | CYS135 |
| B | HIS147 |
| B | HIS152 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1283 |
| Chain | Residue |
| A | ARG124 |
| A | TYR126 |
| A | THR214 |
| A | ARG215 |
| A | HOH2114 |
| A | HOH2116 |
| A | HOH2162 |
| A | HOH2192 |
| A | HOH2193 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1284 |
| Chain | Residue |
| A | HIS244 |
| A | HOH2194 |
| B | TRP137 |
| B | HIS147 |
| B | HIS150 |
| B | GLN151 |
| B | HOH2027 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1283 |
| Chain | Residue |
| B | ASN220 |
| B | ASN270 |
| B | HOH2086 |
| B | HOH2127 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1284 |
| Chain | Residue |
| B | ARG124 |
| B | TYR126 |
| B | THR214 |
| B | ARG215 |
| B | HIS244 |
| B | HOH2082 |
| B | HOH2084 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1285 |
| Chain | Residue |
| A | GLN151 |
| A | HIS152 |
| A | LYS153 |
| A | SER154 |
| A | HOH2029 |
| A | HOH2058 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1293 |
| Chain | Residue |
| A | HOH2152 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 1285 |
| Chain | Residue |
| B | TYR100 |
| B | HIS244 |
| B | HOH2015 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 1286 |
| Chain | Residue |
| A | ARG232 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1286 |
| Chain | Residue |
| A | HOH2127 |
| B | ARG231 |
| B | HOH2132 |
| B | HOH2133 |
| site_id | BC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1287 |
| Chain | Residue |
| A | GLY246 |
| A | ILE247 |
| A | ALA248 |
| A | HOH2028 |
| A | HOH2163 |
| A | HOH2164 |
| A | HOH2166 |
| A | HOH2195 |
| B | MET149 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL A 1288 |
| Chain | Residue |
| A | ASN228 |
| A | GLY229 |
| A | HIS230 |
| A | LEU266 |
| A | PHE267 |
| A | ALA268 |
| A | GLU269 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1287 |
| Chain | Residue |
| B | ASN228 |
| B | HIS230 |
| B | LEU266 |
| B | PHE267 |
| B | ALA268 |
| B | GLU269 |
| B | HOH2098 |
| B | HOH2103 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1288 |
| Chain | Residue |
| B | PRO129 |
| B | GLY246 |
| B | ILE247 |
| B | ALA248 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1289 |
| Chain | Residue |
| A | ARG231 |
| B | GLU237 |
| B | ALA238 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1289 |
| Chain | Residue |
| B | PHE187 |
| B | GLN217 |
| B | ASN220 |
| B | PHE221 |
| B | GLN265 |
| B | HOH2057 |
| B | HOH2086 |
| B | HOH2134 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1290 |
| Chain | Residue |
| B | LYS153 |
| B | SER154 |
| B | HIS152 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1291 |
| Chain | Residue |
| B | SER93 |
| B | VAL94 |
| B | PHE96 |
| B | PRO110 |
| B | HIS111 |
| B | HOH2009 |
| B | HOH2135 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1290 |
| Chain | Residue |
| A | ARG224 |
| A | HOH2196 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1291 |
| Chain | Residue |
| A | GLU161 |
| A | PHE185 |
| A | GLY186 |
| A | PHE187 |
| A | HOH2099 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1292 |
| Chain | Residue |
| A | THR168 |
| A | VAL176 |
| A | ASP177 |
| A | TRP178 |
| A | HOH2091 |
| A | HOH2093 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 120 |
| Details | Zinc finger: {"description":"SIAH-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00455","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28546513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5WZZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16085652","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28546513","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2A25","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5WZZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
