4C9Q
Structure of yeast mitochondrial ADP/ATP carrier isoform 3 inhibited by carboxyatractyloside (P21 crystal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005471 | molecular_function | ATP:ADP antiporter activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015886 | biological_process | heme transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0071705 | biological_process | nitrogen compound transport |
| A | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| A | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
| B | 0005471 | molecular_function | ATP:ADP antiporter activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015886 | biological_process | heme transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0071705 | biological_process | nitrogen compound transport |
| B | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| B | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CXT A 401 |
| Chain | Residue |
| A | ARG85 |
| A | ASN93 |
| A | LYS97 |
| A | PRO184 |
| A | GLY188 |
| A | ARG193 |
| A | SER234 |
| A | ASP238 |
| A | ARG241 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CDL A 800 |
| Chain | Residue |
| A | TRP76 |
| A | ARG77 |
| A | GLY78 |
| A | ASN79 |
| A | THR80 |
| A | VAL83 |
| A | GLY161 |
| A | LEU162 |
| A | THR163 |
| B | LYS167 |
| site_id | AC3 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL A 801 |
| Chain | Residue |
| A | GLY58 |
| A | ILE59 |
| A | VAL60 |
| A | THR232 |
| A | PHE274 |
| A | GLY276 |
| A | CYS277 |
| A | GLY278 |
| A | ALA279 |
| A | ILE281 |
| B | VAL270 |
| B | CDL801 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE CDL A 802 |
| Chain | Residue |
| A | ALA176 |
| A | TYR179 |
| A | ARG180 |
| A | GLY181 |
| A | PHE182 |
| A | MET183 |
| A | PRO184 |
| A | VAL187 |
| A | LEU237 |
| A | MET244 |
| A | GLY256 |
| A | ALA257 |
| A | ILE258 |
| B | MET183 |
| B | ILE258 |
| B | CDL802 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CXT B 401 |
| Chain | Residue |
| B | ARG85 |
| B | ASN93 |
| B | LYS97 |
| B | GLY188 |
| B | ILE189 |
| B | ARG193 |
| B | SER234 |
| B | ASP238 |
| B | ARG241 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CDL B 800 |
| Chain | Residue |
| A | TYR166 |
| A | LYS167 |
| A | LEU170 |
| B | TRP76 |
| B | GLY78 |
| B | ASN79 |
| B | THR80 |
| B | VAL83 |
| B | LEU162 |
| B | THR163 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE CDL B 801 |
| Chain | Residue |
| A | VAL270 |
| A | CDL801 |
| B | GLY58 |
| B | ILE59 |
| B | VAL60 |
| B | THR232 |
| B | PHE274 |
| B | LYS275 |
| B | GLY276 |
| B | CYS277 |
| B | GLY278 |
| B | ALA279 |
| B | ILE281 |
| site_id | AC8 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL B 802 |
| Chain | Residue |
| A | ILE258 |
| A | CDL802 |
| B | TYR179 |
| B | ARG180 |
| B | GLY181 |
| B | PHE182 |
| B | VAL187 |
| B | LEU237 |
| B | MET244 |
| B | GLY256 |
| B | ALA257 |
| B | ILE258 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:24474793 |
| Chain | Residue | Details |
| A | PHE12-LEU39 | |
| B | PHE12-LEU39 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:24474793 |
| Chain | Residue | Details |
| A | THR80-PHE104 | |
| B | THR80-PHE104 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:24474793 |
| Chain | Residue | Details |
| A | TYR112-LEU132 | |
| B | TYR112-LEU132 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:24474793 |
| Chain | Residue | Details |
| A | PHE182-LEU203 | |
| B | PHE182-LEU203 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:24474793 |
| Chain | Residue | Details |
| A | LEU217-LEU237 | |
| B | LEU217-LEU237 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000250|UniProtKB:P18239 |
| Chain | Residue | Details |
| A | CYS277-LEU297 | |
| B | CYS277-LEU297 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24474793 |
| Chain | Residue | Details |
| A | ARG85 | |
| A | LYS97 | |
| A | ARG241 | |
| B | ARG85 | |
| B | LYS97 | |
| B | ARG241 |
