4C9H
Structure of yeast mitochondrial ADP/ATP carrier isoform 2 inhibited by carboxyatractyloside (P212121 crystal form)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005471 | molecular_function | ATP:ADP antiporter activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005743 | cellular_component | mitochondrial inner membrane |
| A | 0006839 | biological_process | mitochondrial transport |
| A | 0006915 | biological_process | apoptotic process |
| A | 0009060 | biological_process | aerobic respiration |
| A | 0009061 | biological_process | anaerobic respiration |
| A | 0015297 | molecular_function | antiporter activity |
| A | 0015866 | biological_process | ADP transport |
| A | 0015867 | biological_process | ATP transport |
| A | 0015886 | biological_process | heme transport |
| A | 0016020 | cellular_component | membrane |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| A | 1901612 | molecular_function | cardiolipin binding |
| A | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
| B | 0005471 | molecular_function | ATP:ADP antiporter activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005743 | cellular_component | mitochondrial inner membrane |
| B | 0006839 | biological_process | mitochondrial transport |
| B | 0006915 | biological_process | apoptotic process |
| B | 0009060 | biological_process | aerobic respiration |
| B | 0009061 | biological_process | anaerobic respiration |
| B | 0015297 | molecular_function | antiporter activity |
| B | 0015866 | biological_process | ADP transport |
| B | 0015867 | biological_process | ATP transport |
| B | 0015886 | biological_process | heme transport |
| B | 0016020 | cellular_component | membrane |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0140021 | biological_process | mitochondrial ADP transmembrane transport |
| B | 1901612 | molecular_function | cardiolipin binding |
| B | 1990544 | biological_process | mitochondrial ATP transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CXT A 401 |
| Chain | Residue |
| A | ARG96 |
| A | LYS108 |
| A | SER141 |
| A | GLY199 |
| A | ARG204 |
| A | ASP249 |
| A | ARG252 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CDL A 800 |
| Chain | Residue |
| A | GLY89 |
| A | ASN90 |
| A | THR91 |
| A | ILE174 |
| A | TRP87 |
| A | ARG88 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CDL A 801 |
| Chain | Residue |
| A | ILE51 |
| A | GLY69 |
| A | ILE70 |
| A | LEU71 |
| A | PHE285 |
| A | LYS286 |
| A | GLY287 |
| A | CYS288 |
| A | GLY289 |
| A | ALA290 |
| B | CDL801 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE CDL A 802 |
| Chain | Residue |
| A | ARG191 |
| A | GLY192 |
| A | PHE193 |
| A | LEU194 |
| A | VAL198 |
| A | LEU248 |
| A | GLY267 |
| A | ALA268 |
| A | PHE269 |
| B | LEU194 |
| B | PHE269 |
| B | CDL802 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE CXT B 401 |
| Chain | Residue |
| B | ARG96 |
| B | ASN104 |
| B | LYS108 |
| B | GLY199 |
| B | ILE200 |
| B | TYR203 |
| B | ARG204 |
| B | PHE208 |
| B | SER245 |
| B | ASP249 |
| B | ARG252 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CDL B 800 |
| Chain | Residue |
| B | TRP87 |
| B | ARG88 |
| B | GLY89 |
| B | ASN90 |
| B | THR91 |
| B | LEU173 |
| B | ILE174 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CDL B 801 |
| Chain | Residue |
| A | CDL801 |
| A | CM51319 |
| B | ILE51 |
| B | GLY69 |
| B | ILE70 |
| B | LEU71 |
| B | PHE285 |
| B | LYS286 |
| B | GLY287 |
| B | CYS288 |
| B | GLY289 |
| B | ALA290 |
| B | ILE292 |
| B | LEU293 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CDL B 802 |
| Chain | Residue |
| A | LEU194 |
| A | CDL802 |
| B | LEU143 |
| B | PHE144 |
| B | ALA187 |
| B | TYR190 |
| B | ARG191 |
| B | GLY192 |
| B | LEU194 |
| B | VAL198 |
| B | MET255 |
| B | GLY267 |
| B | ALA268 |
| B | PHE269 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CM5 A 1319 |
| Chain | Residue |
| A | GLU120 |
| A | GLU279 |
| A | VAL281 |
| A | GLY282 |
| A | SER283 |
| B | LEU71 |
| B | LYS75 |
| B | CDL801 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 48 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 42 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 40 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 93 |
| Details | Repeat: {"description":"Solcar 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for transport activity","evidences":[{"source":"UniProtKB","id":"P12235","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 10 |
| Details | Motif: {"description":"Nucleotide carrier signature motif","evidences":[{"source":"UniProtKB","id":"P02722","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"24474793","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
