Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4C7R

Inward facing conformation of the trimeric betaine transporter BetP in complex with lipids

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0015293	molecular_function	symporter activity
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0055085	biological_process	transmembrane transport
A	0071705	biological_process	nitrogen compound transport
B	0005886	cellular_component	plasma membrane
B	0015293	molecular_function	symporter activity
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0055085	biological_process	transmembrane transport
B	0071705	biological_process	nitrogen compound transport
C	0005886	cellular_component	plasma membrane
C	0015293	molecular_function	symporter activity
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0055085	biological_process	transmembrane transport
C	0071705	biological_process	nitrogen compound transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FLC A 1001

Chain	Residue
A	ALA148
A	GLY149
A	GLY151
A	TRP377
A	PHE380

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FLC B 1001

Chain	Residue
B	TRP377
B	ALA147
B	ALA148
B	GLY149
B	MET150

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FLC C 1001

Chain	Residue
C	ALA148
C	MET150
C	TRP377
C	PHE380
C	HOH2006
C	HOH2014
C	HOH2020

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 1562

Chain	Residue
C	ARG126
C	ASP131
C	ARG210
C	ILE549

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 1553

Chain	Residue
B	ARG126
B	ARG210

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 1587

Chain	Residue
A	ASN177
A	GLY179
B	ALA355

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 1563

Chain	Residue
B	GLY179
C	ALA355

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 1564

Chain	Residue
A	ALA355
C	ASN177
C	GLY179

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGT A 1588

Chain	Residue
A	ALA119
A	LEU399
A	PGT1589
A	PGT1591
A	PGT1592
B	SER120
B	LYS121
B	PGT1554

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGT B 1554

Chain	Residue
A	PGT1588
A	PGT1592
B	PHE112
B	PHE113
B	ALA119
B	VAL541
B	TYR550

site_id	BC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PGT A 1589

Chain	Residue
A	PHE112
A	SER120
A	LYS121
A	PGT1588
A	PGT1590
A	PGT1591
A	PGT1592
C	SER120
C	LYS121
C	LEU191
C	ARG395
C	LEU399
C	LEU403

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGT C 1565

Chain	Residue
C	SER143
C	MET150
C	MET310
C	VAL311
C	ALA313
C	ALA314
C	ILE318
C	PGT1566

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGT C 1566

Chain	Residue
A	ASN98
C	VAL322
C	VAL323
C	GLY324
C	THR326
C	PGT1565

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PGT A 1590

Chain	Residue
A	VAL116
A	ARG554
A	ARG558
A	PGT1589
C	ARG126
C	SER393
C	ARG395
C	GLU396

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGT A 1591

Chain	Residue
A	PHE345
A	PGT1588
A	PGT1589
B	PHE345
C	LEU341

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PGT A 1592

Chain	Residue
A	PGT1588
A	PGT1589
B	ALA118
B	ALA119
B	ARG395
B	PGT1554
C	TYR550

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGT C 1567

Chain	Residue
C	PHE538
C	VAL541
C	LYS542
C	CM51568

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CM5 C 1568

Chain	Residue
C	ILE238
C	PGT1567
C	ILE225
C	LYS228

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FLC C 1569

Chain	Residue
C	ARG167
C	ASN168
C	GLU175

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG B 1555

Chain	Residue
B	SER306
B	PHE384
B	THR467
B	SER471

Functional Information from PROSITE/UniProt

site_id	PS01303
Number of Residues	10
Details	BCCT BCCT family of transporters signature. SWTIfYWaWW

Chain	Residue	Details
A	SER365-TRP374

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	738
Details	TRANSMEM: Helical => ECO:0000269\|PubMed:24141878

Chain	Residue	Details
A	TRP60-PHE80
A	ILE452-MET476
A	TRP490-GLY510
A	VAL521-VAL541
B	TRP60-PHE80
B	LEU99-ALA119
B	THR138-GLY158
B	MET186-TYR206
B	LEU237-GLY257
B	TRP277-SER296
B	LYS300-VAL323
A	LEU99-ALA119
B	TRP366-ALA386
B	PHE397-GLY417
B	ILE452-MET476
B	TRP490-GLY510
B	VAL521-VAL541
C	TRP60-PHE80
C	LEU99-ALA119
C	THR138-GLY158
C	MET186-TYR206
C	LEU237-GLY257
A	THR138-GLY158
C	TRP277-SER296
C	LYS300-VAL323
C	TRP366-ALA386
C	PHE397-GLY417
C	ILE452-MET476
C	TRP490-GLY510
C	VAL521-VAL541
A	MET186-TYR206
A	LEU237-GLY257
A	TRP277-SER296
A	LYS300-VAL323
A	TRP366-ALA386
A	PHE397-GLY417

site_id	SWS_FT_FI2
Number of Residues	432
Details	TOPO_DOM: Periplasmic => ECO:0000305

Chain	Residue	Details
A	LYS81-ASN98
B	GLY324-SER365
B	GLY418-GLN451
B	GLY511-ASN520
C	LYS81-ASN98
C	THR159-THR185
C	ALA258-ASP276
C	GLY324-SER365
C	GLY418-GLN451
C	GLY511-ASN520
A	THR159-THR185
A	ALA258-ASP276
A	GLY324-SER365
A	GLY418-GLN451
A	GLY511-ASN520
B	LYS81-ASN98
B	THR159-THR185
B	ALA258-ASP276

site_id	SWS_FT_FI3
Number of Residues	207
Details	TOPO_DOM: Cytoplasmic => ECO:0000305

Chain	Residue	Details
A	SER120-ARG137
B	GLY477-LYS489
C	SER120-ARG137
C	SER207-LYS236
C	GLY297-GLY299
C	ARG387-GLU396
C	GLY477-LYS489
A	SER207-LYS236
A	GLY297-GLY299
A	ARG387-GLU396
A	GLY477-LYS489
B	SER120-ARG137
B	SER207-LYS236
B	GLY297-GLY299
B	ARG387-GLU396

site_id	SWS_FT_FI4
Number of Residues	159
Details	TOPO_DOM: Cytoplasmic => ECO:0000305\|PubMed:9446558

Chain	Residue	Details
A	LYS542-ARG595
B	LYS542-ARG595
C	LYS542-ARG595

site_id	SWS_FT_FI5
Number of Residues	6
Details	BINDING: BINDING => ECO:0000305\|PubMed:19262666, ECO:0000305\|PubMed:22940865, ECO:0000305\|PubMed:25023443

Chain	Residue	Details
A	ALA147
A	MET150
B	ALA147
B	MET150
C	ALA147
C	MET150

site_id	SWS_FT_FI6
Number of Residues	9
Details	BINDING: BINDING => ECO:0000305\|PubMed:19262666

Chain	Residue	Details
A	ALA148
A	SER306
A	MET310
B	ALA148
B	SER306
B	MET310
C	ALA148
C	SER306
C	MET310

site_id	SWS_FT_FI7
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:22940865, ECO:0007744\|PDB:4AIN

Chain	Residue	Details
A	ILE152
A	SER253
B	ILE152
B	SER253
C	ILE152
C	SER253

site_id	SWS_FT_FI8
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:19262666, ECO:0000269\|PubMed:22940865, ECO:0007744\|PDB:4AIN

Chain	Residue	Details
A	TRP373
B	TRP373
C	TRP373

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)