4C7G
Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016231 | molecular_function | beta-N-acetylglucosaminidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030203 | biological_process | glycosaminoglycan metabolic process |
| A | 0102148 | molecular_function | N-acetyl-beta-D-galactosaminidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE NGO A 1495 |
| Chain | Residue |
| A | ARG150 |
| A | TRP396 |
| A | TRP430 |
| A | GLU432 |
| A | EDO1499 |
| A | HOH2170 |
| A | HIS238 |
| A | ASP301 |
| A | GLN302 |
| A | TRP332 |
| A | TRP349 |
| A | TYR381 |
| A | ASP383 |
| A | LEU394 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1496 |
| Chain | Residue |
| A | ASP352 |
| A | LYS359 |
| A | TYR413 |
| A | PRO415 |
| A | HOH2348 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1497 |
| Chain | Residue |
| A | HIS226 |
| A | GLU228 |
| A | HOH2252 |
| A | HOH2446 |
| A | HOH2447 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1498 |
| Chain | Residue |
| A | SER224 |
| A | HIS226 |
| A | HOH2056 |
| A | HOH2251 |
| A | HOH2253 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1499 |
| Chain | Residue |
| A | GLN302 |
| A | TRP396 |
| A | NGO1495 |
| A | HOH2448 |
| A | HOH2449 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1500 |
| Chain | Residue |
| A | HIS333 |
| A | GLN334 |
| A | TRP349 |
| A | THR354 |
| A | GLU358 |
| A | HOH2364 |
| A | HOH2451 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1501 |
| Chain | Residue |
| A | TYR259 |
| A | PHE266 |
| A | HOH2453 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1502 |
| Chain | Residue |
| A | HIS333 |
| A | GLN334 |
| A | ALA336 |
| A | GLY337 |
| A | GLU358 |
| A | GLN361 |
| A | HOH2339 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1503 |
| Chain | Residue |
| A | ALA303 |
| A | THR306 |
| A | PHE311 |
| A | HOH2312 |
| A | HOH2315 |
| A | HOH2319 |
| A | HOH2454 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1504 |
| Chain | Residue |
| A | HIS30 |
| A | ARG57 |
| A | ASP484 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 1505 |
| Chain | Residue |
| A | SER86 |
| A | GLY131 |
| A | THR132 |
| A | HOH2021 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1506 |
| Chain | Residue |
| A | ASP272 |
| A | ASP274 |
| A | ARG317 |
