4C7F
Structure and activity of the GH20 beta-N-acetylhexosaminidase from Streptomyces coelicolor A3(2)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0030203 | biological_process | glycosaminoglycan metabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0030203 | biological_process | glycosaminoglycan metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1495 |
| Chain | Residue |
| A | HIS333 |
| A | GLN334 |
| A | TRP349 |
| A | THR354 |
| A | GLU358 |
| A | HOH2434 |
| A | HOH2540 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1495 |
| Chain | Residue |
| B | ASP389 |
| B | THR390 |
| B | PRO391 |
| B | HOH2579 |
| B | HOH2580 |
| A | ASP214 |
| B | LYS388 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1496 |
| Chain | Residue |
| A | ARG40 |
| A | ASP44 |
| A | HOH2090 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1496 |
| Chain | Residue |
| A | ARG71 |
| B | ASP274 |
| B | ARG317 |
| B | EDO1497 |
| B | HOH2413 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1497 |
| Chain | Residue |
| A | VAL271 |
| A | ARG317 |
| A | HOH2541 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1497 |
| Chain | Residue |
| A | ARG69 |
| A | ARG71 |
| A | HOH2059 |
| B | ASP274 |
| B | TYR277 |
| B | ASP278 |
| B | ARG317 |
| B | EDO1496 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1498 |
| Chain | Residue |
| B | ASN240 |
| B | PRO256 |
| B | PRO257 |
| B | HOH2347 |
| B | HOH2581 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 1498 |
| Chain | Residue |
| A | THR268 |
| A | LEU269 |
| A | CYS270 |
| A | VAL271 |
| A | PRO307 |
| A | ASP310 |
| A | HOH2359 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1499 |
| Chain | Residue |
| A | ASP352 |
| A | LYS359 |
| A | TYR413 |
| A | PRO415 |
| A | HOH2415 |
| A | HOH2542 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1499 |
| Chain | Residue |
| B | ASP352 |
| B | LYS359 |
| B | TYR413 |
| B | PRO415 |
| B | HOH2441 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 1500 |
| Chain | Residue |
| A | ALA366 |
| A | HOH2490 |
| B | SER355 |
| B | ASP356 |
| B | ALA357 |
| B | EDO1503 |
| B | HOH2582 |
| B | HOH2583 |
| B | HOH2584 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1501 |
| Chain | Residue |
| A | GLU420 |
| A | HOH2483 |
| A | HOH2484 |
| B | GLU358 |
| B | GLN361 |
| B | HOH2585 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1500 |
| Chain | Residue |
| A | ARG138 |
| A | HOH2218 |
| A | HOH2486 |
| A | HOH2543 |
| A | HOH2544 |
| site_id | BC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO B 1502 |
| Chain | Residue |
| B | TYR23 |
| B | THR26 |
| B | GLY28 |
| B | THR29 |
| B | GLY67 |
| B | EDO1507 |
| B | HOH2041 |
| B | HOH2149 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1501 |
| Chain | Residue |
| A | ASP188 |
| A | SER189 |
| A | PRO191 |
| B | HIS30 |
| B | GLY64 |
| B | HIS65 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1502 |
| Chain | Residue |
| A | ASP85 |
| A | SER86 |
| A | GLY131 |
| A | HOH2035 |
| A | HOH2546 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1503 |
| Chain | Residue |
| B | EDO1500 |
| B | HOH2442 |
| B | HOH2457 |
| A | ARG367 |
| A | GLY369 |
| B | SER355 |
| B | ASP356 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1503 |
| Chain | Residue |
| A | ASN240 |
| A | PRO257 |
| A | LEU258 |
| A | TYR259 |
| A | HOH2343 |
| A | HOH2547 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1504 |
| Chain | Residue |
| B | LYS468 |
| B | PRO489 |
| B | GLN490 |
| B | VAL491 |
| B | PRO492 |
| B | HOH2586 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1505 |
| Chain | Residue |
| B | ARG403 |
| B | HOH2553 |
| B | HOH2555 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 1506 |
| Chain | Residue |
| B | SER86 |
| B | GLU89 |
| B | GLY131 |
| B | THR132 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 1507 |
| Chain | Residue |
| B | HIS65 |
| B | EDO1502 |
| B | HOH2147 |
| B | HOH2587 |
| B | HOH2588 |
| B | HOH2589 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 1504 |
| Chain | Residue |
| A | PHE152 |
| A | GLU157 |
| A | SER435 |
| A | ASP436 |
| A | PRO437 |
| A | HOH2228 |
| A | HOH2236 |
| A | HOH2548 |
| A | HOH2549 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1505 |
| Chain | Residue |
| A | GLU80 |
| A | LYS172 |
| A | ARG294 |
| A | HOH2253 |
| A | HOH2374 |
| A | HOH2550 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 1506 |
| Chain | Residue |
| A | ARG138 |
| A | ALA140 |
| A | HOH2136 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 1508 |
| Chain | Residue |
| B | HIS333 |
| B | GLN334 |
| B | TRP349 |
| B | THR354 |
| B | GLU358 |
| B | HOH2428 |
| B | HOH2460 |
| site_id | CC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1507 |
| Chain | Residue |
| A | PRO137 |
| A | ARG138 |
| A | PRO458 |
| A | HOH2206 |
| A | HOH2209 |
| A | HOH2505 |
| A | HOH2543 |
| A | HOH2551 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1508 |
| Chain | Residue |
| A | GLY87 |
| A | GLY90 |
| A | VAL91 |
| A | THR92 |
| A | HOH2150 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1509 |
| Chain | Residue |
| A | VAL42 |
| A | SER224 |
| A | HIS226 |
| A | HOH2068 |
| A | HOH2309 |
| A | HOH2552 |
| site_id | DC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE EDO A 1510 |
| Chain | Residue |
| A | PRO410 |
| A | ALA411 |
| A | ALA412 |
| A | TYR413 |
| A | LEU414 |
| A | ALA417 |
| A | VAL422 |
| A | HOH2553 |
| site_id | DC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 1509 |
| Chain | Residue |
| B | ARG353 |
| B | HOH2591 |
| B | HOH2592 |
| site_id | DC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GC2 B 1510 |
| Chain | Residue |
| B | ARG150 |
| B | VAL264 |
| B | ASP301 |
| B | GLU302 |
| B | TRP332 |
| B | TRP349 |
| B | TYR381 |
| B | TRP396 |
| B | TRP430 |
| B | GLU432 |
| B | HOH2269 |
| B | HOH2356 |
| B | HOH2479 |
| B | HOH2593 |
| site_id | DC6 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GC2 A 1511 |
| Chain | Residue |
| A | ARG150 |
| A | VAL264 |
| A | ASP301 |
| A | GLU302 |
| A | TRP332 |
| A | TRP349 |
| A | TYR381 |
| A | TRP396 |
| A | TRP430 |
| A | GLU432 |
| A | HOH2257 |
| A | HOH2349 |
| A | HOH2448 |
| A | HOH2554 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 1512 |
| Chain | Residue |
| A | ARG24 |
| A | THR26 |
| A | ARG27 |
| A | TYR56 |
| B | HOH2202 |
