4C4A
Crystal structure of mouse protein arginine methyltransferase 7 in complex with SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000387 | biological_process | spliceosomal snRNP assembly |
| A | 0001650 | cellular_component | fibrillar center |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006479 | biological_process | protein methylation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0008757 | molecular_function | S-adenosylmethionine-dependent methyltransferase activity |
| A | 0016274 | molecular_function | protein-arginine N-methyltransferase activity |
| A | 0018216 | biological_process | peptidyl-arginine methylation |
| A | 0035241 | molecular_function | protein-arginine omega-N monomethyltransferase activity |
| A | 0035243 | molecular_function | protein-arginine omega-N symmetric methyltransferase activity |
| A | 0042393 | molecular_function | histone binding |
| A | 0043021 | molecular_function | ribonucleoprotein complex binding |
| A | 0044020 | molecular_function | histone H4R3 methyltransferase activity |
| A | 0071514 | biological_process | genomic imprinting |
| A | 0140939 | molecular_function | histone H4 methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH A 1689 |
| Chain | Residue |
| A | TYR35 |
| A | HIS122 |
| A | SER123 |
| A | GLU144 |
| A | LEU145 |
| A | SER158 |
| A | HOH5096 |
| A | HOH5097 |
| A | HOH5103 |
| A | HOH5223 |
| A | HOH5692 |
| A | MET38 |
| A | ARG44 |
| A | GLY72 |
| A | THR73 |
| A | LEU78 |
| A | GLU94 |
| A | VAL95 |
| A | LYS121 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DMX A 2690 |
| Chain | Residue |
| A | ARG458 |
| A | THR483 |
| A | LEU491 |
| A | TYR492 |
| A | PRO676 |
| A | LEU677 |
| A | THR678 |
| A | HOH5575 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG0 A 3691 |
| Chain | Residue |
| A | HIS371 |
| A | LEU372 |
| A | LEU373 |
| A | ASN375 |
| A | HOH5471 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 4692 |
| Chain | Residue |
| A | CYS219 |
| A | CYS366 |
| A | CYS368 |
| A | HIS371 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
