4C4A

Crystal structure of mouse protein arginine methyltransferase 7 in complex with SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000387	biological_process	spliceosomal snRNP assembly
A	0001650	cellular_component	fibrillar center
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006479	biological_process	protein methylation
A	0008168	molecular_function	methyltransferase activity
A	0008757	molecular_function	S-adenosylmethionine-dependent methyltransferase activity
A	0016274	molecular_function	protein-arginine N-methyltransferase activity
A	0016740	molecular_function	transferase activity
A	0018216	biological_process	peptidyl-arginine methylation
A	0030154	biological_process	cell differentiation
A	0032259	biological_process	methylation
A	0035241	molecular_function	protein-arginine omega-N monomethyltransferase activity
A	0035243	molecular_function	protein-arginine omega-N symmetric methyltransferase activity
A	0042054	molecular_function	histone methyltransferase activity
A	0042393	molecular_function	histone binding
A	0043021	molecular_function	ribonucleoprotein complex binding
A	0044020	molecular_function	histone H4R3 methyltransferase activity
A	0071514	biological_process	genomic imprinting
A	0140939	molecular_function	histone H4 methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAH A 1689

Chain	Residue
A	TYR35
A	HIS122
A	SER123
A	GLU144
A	LEU145
A	SER158
A	HOH5096
A	HOH5097
A	HOH5103
A	HOH5223
A	HOH5692
A	MET38
A	ARG44
A	GLY72
A	THR73
A	LEU78
A	GLU94
A	VAL95
A	LYS121

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DMX A 2690

Chain	Residue
A	ARG458
A	THR483
A	LEU491
A	TYR492
A	PRO676
A	LEU677
A	THR678
A	HOH5575

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site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG0 A 3691

Chain	Residue
A	HIS371
A	LEU372
A	LEU373
A	ASN375
A	HOH5471

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 4692

Chain	Residue
A	CYS219
A	CYS366
A	CYS368
A	HIS371

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	GLU144
A	GLU153

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0007744|PubMed:24129315

Chain	Residue	Details
A	ARG32

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