4C48
Crystal structure of AcrB-AcrZ complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009279 | cellular_component | cell outer membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0036460 | biological_process | cellular response to cell envelope stress |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2038 |
| Chain | Residue |
| A | LMT2039 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LMT A 2039 |
| Chain | Residue |
| A | LMT2038 |
| A | LMT2043 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A 2040 |
| Chain | Residue |
| A | HIS525 |
| A | ASP529 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2041 |
| Chain | Residue |
| A | LMT2046 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LMT A 2042 |
| Chain | Residue |
| A | MET1 |
| A | ASN3 |
| A | LMT2043 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMT A 2043 |
| Chain | Residue |
| A | ARG8 |
| A | GLN439 |
| A | GLY440 |
| A | LEU891 |
| A | GLU947 |
| A | LYS950 |
| A | LMT2039 |
| A | LMT2042 |
| A | LMT2047 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2044 |
| Chain | Residue |
| A | ILE390 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2046 |
| Chain | Residue |
| A | LMT2041 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2047 |
| Chain | Residue |
| A | LMT2043 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | TOPO_DOM: Periplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | MET1-SER7 | |
| A | LEU357-THR365 | |
| A | GLU414-ILE438 | |
| A | ALA491-THR538 | |
| A | ALA889-PRO898 | |
| A | LEU944-LEU972 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | TRANSMEM: Helical => ECO:0000255|HAMAP-Rule:MF_01484 |
| Chain | Residue | Details |
| C | LEU8-GLY28 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
| Chain | Residue | Details |
| C | LEU29-HIS49 | |
| A | PHE386-ASN391 | |
| A | PHE458-ALA465 | |
| A | PHE556-ASN871 | |
| A | ARG919-ASP924 | |
| A | THR993-GLY998 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=2 |
| Chain | Residue | Details |
| A | ILE337-TYR356 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=3 |
| Chain | Residue | Details |
| A | LEU366-ALA385 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | TRANSMEM: Helical; Name=4 |
| Chain | Residue | Details |
| A | THR392-VAL413 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=5 |
| Chain | Residue | Details |
| A | GLN439-ALA457 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=6 |
| Chain | Residue | Details |
| A | ILE466-PRO490 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=7 |
| Chain | Residue | Details |
| A | GLY539-LEU555 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | TRANSMEM: Helical; Name=8 |
| Chain | Residue | Details |
| A | GLN872-LEU888 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=9 |
| Chain | Residue | Details |
| A | PHE899-PHE918 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | TRANSMEM: Helical; Name=10 |
| Chain | Residue | Details |
| A | VAL925-ILE943 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=11 |
| Chain | Residue | Details |
| A | ARG973-SER992 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | TRANSMEM: Helical; Name=12 |
| Chain | Residue | Details |
| A | ALA999-ALA1018 |
