4C48
Crystal structure of AcrB-AcrZ complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0009410 | biological_process | response to xenobiotic stimulus |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0015125 | molecular_function | bile acid transmembrane transporter activity |
| A | 0015562 | molecular_function | efflux transmembrane transporter activity |
| A | 0015567 | molecular_function | alkane transmembrane transporter activity |
| A | 0015721 | biological_process | bile acid and bile salt transport |
| A | 0015895 | biological_process | alkane transport |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016020 | cellular_component | membrane |
| A | 0022857 | molecular_function | transmembrane transporter activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042908 | biological_process | xenobiotic transport |
| A | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| A | 0042930 | biological_process | enterobactin transport |
| A | 0042931 | molecular_function | enterobactin transmembrane transporter activity |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098567 | cellular_component | periplasmic side of plasma membrane |
| A | 0140330 | biological_process | xenobiotic detoxification by transmembrane export across the cell outer membrane |
| A | 1990281 | cellular_component | efflux pump complex |
| C | 0005515 | molecular_function | protein binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0009279 | cellular_component | cell outer membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0042910 | molecular_function | xenobiotic transmembrane transporter activity |
| C | 0046677 | biological_process | response to antibiotic |
| C | 1990961 | biological_process | xenobiotic detoxification by transmembrane export across the plasma membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2038 |
| Chain | Residue |
| A | LMT2039 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE LMT A 2039 |
| Chain | Residue |
| A | LMT2038 |
| A | LMT2043 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI A 2040 |
| Chain | Residue |
| A | HIS525 |
| A | ASP529 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2041 |
| Chain | Residue |
| A | LMT2046 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE LMT A 2042 |
| Chain | Residue |
| A | MET1 |
| A | ASN3 |
| A | LMT2043 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE LMT A 2043 |
| Chain | Residue |
| A | ARG8 |
| A | GLN439 |
| A | GLY440 |
| A | LEU891 |
| A | GLU947 |
| A | LYS950 |
| A | LMT2039 |
| A | LMT2042 |
| A | LMT2047 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2044 |
| Chain | Residue |
| A | ILE390 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2046 |
| Chain | Residue |
| A | LMT2041 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE LMT A 2047 |
| Chain | Residue |
| A | LMT2043 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 124 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 329 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"source":"PubMed","id":"15919996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=7"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 16 |
| Details | Transmembrane: {"description":"Helical; Name=8"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=9"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 18 |
| Details | Transmembrane: {"description":"Helical; Name=10"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=11"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 19 |
| Details | Transmembrane: {"description":"Helical; Name=12"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 6 |
| Details | Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"HAMAP-Rule","id":"MF_01484","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
