Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4C3E

HRSV M2-1 mutant S58D S61D, P21 crystal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0008270	molecular_function	zinc ion binding
A	0019083	biological_process	viral transcription
A	0030430	cellular_component	host cell cytoplasm
A	0031564	biological_process	transcription antitermination
A	0042025	cellular_component	host cell nucleus
A	0044423	cellular_component	virion component
A	0046782	biological_process	regulation of viral transcription
A	0046872	molecular_function	metal ion binding
A	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
B	0003723	molecular_function	RNA binding
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0008270	molecular_function	zinc ion binding
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0031564	biological_process	transcription antitermination
B	0042025	cellular_component	host cell nucleus
B	0044423	cellular_component	virion component
B	0046782	biological_process	regulation of viral transcription
B	0046872	molecular_function	metal ion binding
B	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
C	0003723	molecular_function	RNA binding
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0008270	molecular_function	zinc ion binding
C	0019083	biological_process	viral transcription
C	0030430	cellular_component	host cell cytoplasm
C	0031564	biological_process	transcription antitermination
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0046782	biological_process	regulation of viral transcription
C	0046872	molecular_function	metal ion binding
C	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
D	0003723	molecular_function	RNA binding
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0008270	molecular_function	zinc ion binding
D	0019083	biological_process	viral transcription
D	0030430	cellular_component	host cell cytoplasm
D	0031564	biological_process	transcription antitermination
D	0042025	cellular_component	host cell nucleus
D	0044423	cellular_component	virion component
D	0046782	biological_process	regulation of viral transcription
D	0046872	molecular_function	metal ion binding
D	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
E	0003723	molecular_function	RNA binding
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0008270	molecular_function	zinc ion binding
E	0019083	biological_process	viral transcription
E	0030430	cellular_component	host cell cytoplasm
E	0031564	biological_process	transcription antitermination
E	0042025	cellular_component	host cell nucleus
E	0044423	cellular_component	virion component
E	0046782	biological_process	regulation of viral transcription
E	0046872	molecular_function	metal ion binding
E	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
F	0003723	molecular_function	RNA binding
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0008270	molecular_function	zinc ion binding
F	0019083	biological_process	viral transcription
F	0030430	cellular_component	host cell cytoplasm
F	0031564	biological_process	transcription antitermination
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0046782	biological_process	regulation of viral transcription
F	0046872	molecular_function	metal ion binding
F	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
G	0003723	molecular_function	RNA binding
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0008270	molecular_function	zinc ion binding
G	0019083	biological_process	viral transcription
G	0030430	cellular_component	host cell cytoplasm
G	0031564	biological_process	transcription antitermination
G	0042025	cellular_component	host cell nucleus
G	0044423	cellular_component	virion component
G	0046782	biological_process	regulation of viral transcription
G	0046872	molecular_function	metal ion binding
G	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
H	0003723	molecular_function	RNA binding
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0008270	molecular_function	zinc ion binding
H	0019083	biological_process	viral transcription
H	0030430	cellular_component	host cell cytoplasm
H	0031564	biological_process	transcription antitermination
H	0042025	cellular_component	host cell nucleus
H	0044423	cellular_component	virion component
H	0046782	biological_process	regulation of viral transcription
H	0046872	molecular_function	metal ion binding
H	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
I	0003723	molecular_function	RNA binding
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0008270	molecular_function	zinc ion binding
I	0019083	biological_process	viral transcription
I	0030430	cellular_component	host cell cytoplasm
I	0031564	biological_process	transcription antitermination
I	0042025	cellular_component	host cell nucleus
I	0044423	cellular_component	virion component
I	0046782	biological_process	regulation of viral transcription
I	0046872	molecular_function	metal ion binding
I	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
J	0003723	molecular_function	RNA binding
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0008270	molecular_function	zinc ion binding
J	0019083	biological_process	viral transcription
J	0030430	cellular_component	host cell cytoplasm
J	0031564	biological_process	transcription antitermination
J	0042025	cellular_component	host cell nucleus
J	0044423	cellular_component	virion component
J	0046782	biological_process	regulation of viral transcription
J	0046872	molecular_function	metal ion binding
J	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
K	0003723	molecular_function	RNA binding
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0008270	molecular_function	zinc ion binding
K	0019083	biological_process	viral transcription
K	0030430	cellular_component	host cell cytoplasm
K	0031564	biological_process	transcription antitermination
K	0042025	cellular_component	host cell nucleus
K	0044423	cellular_component	virion component
K	0046782	biological_process	regulation of viral transcription
K	0046872	molecular_function	metal ion binding
K	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
L	0003723	molecular_function	RNA binding
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0008270	molecular_function	zinc ion binding
L	0019083	biological_process	viral transcription
L	0030430	cellular_component	host cell cytoplasm
L	0031564	biological_process	transcription antitermination
L	0042025	cellular_component	host cell nucleus
L	0044423	cellular_component	virion component
L	0046782	biological_process	regulation of viral transcription
L	0046872	molecular_function	metal ion binding
L	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
M	0003723	molecular_function	RNA binding
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0008270	molecular_function	zinc ion binding
M	0019083	biological_process	viral transcription
M	0030430	cellular_component	host cell cytoplasm
M	0031564	biological_process	transcription antitermination
M	0042025	cellular_component	host cell nucleus
M	0044423	cellular_component	virion component
M	0046782	biological_process	regulation of viral transcription
M	0046872	molecular_function	metal ion binding
M	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
N	0003723	molecular_function	RNA binding
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0008270	molecular_function	zinc ion binding
N	0019083	biological_process	viral transcription
N	0030430	cellular_component	host cell cytoplasm
N	0031564	biological_process	transcription antitermination
N	0042025	cellular_component	host cell nucleus
N	0044423	cellular_component	virion component
N	0046782	biological_process	regulation of viral transcription
N	0046872	molecular_function	metal ion binding
N	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
O	0003723	molecular_function	RNA binding
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0008270	molecular_function	zinc ion binding
O	0019083	biological_process	viral transcription
O	0030430	cellular_component	host cell cytoplasm
O	0031564	biological_process	transcription antitermination
O	0042025	cellular_component	host cell nucleus
O	0044423	cellular_component	virion component
O	0046782	biological_process	regulation of viral transcription
O	0046872	molecular_function	metal ion binding
O	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
P	0003723	molecular_function	RNA binding
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0008270	molecular_function	zinc ion binding
P	0019083	biological_process	viral transcription
P	0030430	cellular_component	host cell cytoplasm
P	0031564	biological_process	transcription antitermination
P	0042025	cellular_component	host cell nucleus
P	0044423	cellular_component	virion component
P	0046782	biological_process	regulation of viral transcription
P	0046872	molecular_function	metal ion binding
P	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS7
A	CYS15
A	CYS21
A	HIS25

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 201

Chain	Residue
B	CYS7
B	CYS15
B	CYS21
B	HIS25

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	CYS15
C	CYS21
C	HIS25
C	CYS7

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 201

Chain	Residue
D	CYS7
D	CYS15
D	CYS21
D	HIS25

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 201

Chain	Residue
E	CYS7
E	CYS15
E	CYS21
E	HIS25

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 201

Chain	Residue
F	CYS7
F	CYS15
F	CYS21
F	HIS25

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 201

Chain	Residue
G	CYS7
G	CYS15
G	CYS21
G	HIS25

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 201

Chain	Residue
H	CYS7
H	CYS15
H	CYS21
H	HIS25

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 201

Chain	Residue
I	CYS7
I	CYS15
I	CYS21
I	HIS25

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 201

Chain	Residue
J	CYS7
J	CYS15
J	CYS21
J	HIS25

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 201

Chain	Residue
K	CYS7
K	CYS15
K	CYS21
K	HIS25

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 201

Chain	Residue
L	CYS7
L	CYS15
L	CYS21
L	HIS25

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 201

Chain	Residue
M	CYS7
M	CYS15
M	CYS21
M	HIS25

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 201

Chain	Residue
N	CYS7
N	CYS15
N	CYS21
N	HIS25

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O 201

Chain	Residue
O	CYS7
O	CYS15
O	CYS21
O	HIS25

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 201

Chain	Residue
P	CYS7
P	CYS15
P	CYS21
P	HIS25

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	432
Details	ZN_FING: C3H1-type => ECO:0000255\|PROSITE-ProRule:PRU00723, ECO:0000269\|PubMed:24434552, ECO:0000269\|PubMed:32697936

Chain	Residue	Details
A	MET1-PHE28
J	MET1-PHE28
K	MET1-PHE28
L	MET1-PHE28
M	MET1-PHE28
N	MET1-PHE28
O	MET1-PHE28
P	MET1-PHE28
B	MET1-PHE28
C	MET1-PHE28
D	MET1-PHE28
E	MET1-PHE28
F	MET1-PHE28
G	MET1-PHE28
H	MET1-PHE28
I	MET1-PHE28

site_id	SWS_FT_FI2
Number of Residues	80
Details	SITE: Involved in RNA-binding => ECO:0000269\|PubMed:32697936

Chain	Residue	Details
A	LYS8
B	ARG151
C	LYS8
C	PHE9
C	PHE23
C	LYS92
C	ARG151
D	LYS8
D	PHE9
D	PHE23
D	LYS92
A	PHE9
D	ARG151
E	LYS8
E	PHE9
E	PHE23
E	LYS92
E	ARG151
F	LYS8
F	PHE9
F	PHE23
F	LYS92
A	PHE23
F	ARG151
G	LYS8
G	PHE9
G	PHE23
G	LYS92
G	ARG151
H	LYS8
H	PHE9
H	PHE23
H	LYS92
A	LYS92
H	ARG151
I	LYS8
I	PHE9
I	PHE23
I	LYS92
I	ARG151
J	LYS8
J	PHE9
J	PHE23
J	LYS92
A	ARG151
J	ARG151
K	LYS8
K	PHE9
K	PHE23
K	LYS92
K	ARG151
L	LYS8
L	PHE9
L	PHE23
L	LYS92
B	LYS8
L	ARG151
M	LYS8
M	PHE9
M	PHE23
M	LYS92
M	ARG151
N	LYS8
N	PHE9
N	PHE23
N	LYS92
B	PHE9
N	ARG151
O	LYS8
O	PHE9
O	PHE23
O	LYS92
O	ARG151
P	LYS8
P	PHE9
P	PHE23
P	LYS92
B	PHE23
P	ARG151
B	LYS92

site_id	SWS_FT_FI3
Number of Residues	32
Details	MOD_RES: Phosphoserine; by host => ECO:0000269\|PubMed:11711610

Chain	Residue	Details
A	ASP58
E	ASP61
F	ASP58
F	ASP61
G	ASP58
G	ASP61
H	ASP58
H	ASP61
I	ASP58
I	ASP61
J	ASP58
A	ASP61
J	ASP61
K	ASP58
K	ASP61
L	ASP58
L	ASP61
M	ASP58
M	ASP61
N	ASP58
N	ASP61
O	ASP58
B	ASP58
O	ASP61
P	ASP58
P	ASP61
B	ASP61
C	ASP58
C	ASP61
D	ASP58
D	ASP61
E	ASP58

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)