4C3E

HRSV M2-1 mutant S58D S61D, P21 crystal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005198	molecular_function	structural molecule activity
A	0005515	molecular_function	protein binding
A	0008270	molecular_function	zinc ion binding
A	0019083	biological_process	viral transcription
A	0030430	cellular_component	host cell cytoplasm
A	0031564	biological_process	transcription antitermination
A	0042025	cellular_component	host cell nucleus
A	0044423	cellular_component	virion component
A	0046782	biological_process	regulation of viral transcription
A	0046872	molecular_function	metal ion binding
A	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
B	0003723	molecular_function	RNA binding
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0008270	molecular_function	zinc ion binding
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0031564	biological_process	transcription antitermination
B	0042025	cellular_component	host cell nucleus
B	0044423	cellular_component	virion component
B	0046782	biological_process	regulation of viral transcription
B	0046872	molecular_function	metal ion binding
B	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
C	0003723	molecular_function	RNA binding
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0008270	molecular_function	zinc ion binding
C	0019083	biological_process	viral transcription
C	0030430	cellular_component	host cell cytoplasm
C	0031564	biological_process	transcription antitermination
C	0042025	cellular_component	host cell nucleus
C	0044423	cellular_component	virion component
C	0046782	biological_process	regulation of viral transcription
C	0046872	molecular_function	metal ion binding
C	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
D	0003723	molecular_function	RNA binding
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0008270	molecular_function	zinc ion binding
D	0019083	biological_process	viral transcription
D	0030430	cellular_component	host cell cytoplasm
D	0031564	biological_process	transcription antitermination
D	0042025	cellular_component	host cell nucleus
D	0044423	cellular_component	virion component
D	0046782	biological_process	regulation of viral transcription
D	0046872	molecular_function	metal ion binding
D	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
E	0003723	molecular_function	RNA binding
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0008270	molecular_function	zinc ion binding
E	0019083	biological_process	viral transcription
E	0030430	cellular_component	host cell cytoplasm
E	0031564	biological_process	transcription antitermination
E	0042025	cellular_component	host cell nucleus
E	0044423	cellular_component	virion component
E	0046782	biological_process	regulation of viral transcription
E	0046872	molecular_function	metal ion binding
E	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
F	0003723	molecular_function	RNA binding
F	0005198	molecular_function	structural molecule activity
F	0005515	molecular_function	protein binding
F	0008270	molecular_function	zinc ion binding
F	0019083	biological_process	viral transcription
F	0030430	cellular_component	host cell cytoplasm
F	0031564	biological_process	transcription antitermination
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0046782	biological_process	regulation of viral transcription
F	0046872	molecular_function	metal ion binding
F	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
G	0003723	molecular_function	RNA binding
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0008270	molecular_function	zinc ion binding
G	0019083	biological_process	viral transcription
G	0030430	cellular_component	host cell cytoplasm
G	0031564	biological_process	transcription antitermination
G	0042025	cellular_component	host cell nucleus
G	0044423	cellular_component	virion component
G	0046782	biological_process	regulation of viral transcription
G	0046872	molecular_function	metal ion binding
G	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
H	0003723	molecular_function	RNA binding
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0008270	molecular_function	zinc ion binding
H	0019083	biological_process	viral transcription
H	0030430	cellular_component	host cell cytoplasm
H	0031564	biological_process	transcription antitermination
H	0042025	cellular_component	host cell nucleus
H	0044423	cellular_component	virion component
H	0046782	biological_process	regulation of viral transcription
H	0046872	molecular_function	metal ion binding
H	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
I	0003723	molecular_function	RNA binding
I	0005198	molecular_function	structural molecule activity
I	0005515	molecular_function	protein binding
I	0008270	molecular_function	zinc ion binding
I	0019083	biological_process	viral transcription
I	0030430	cellular_component	host cell cytoplasm
I	0031564	biological_process	transcription antitermination
I	0042025	cellular_component	host cell nucleus
I	0044423	cellular_component	virion component
I	0046782	biological_process	regulation of viral transcription
I	0046872	molecular_function	metal ion binding
I	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
J	0003723	molecular_function	RNA binding
J	0005198	molecular_function	structural molecule activity
J	0005515	molecular_function	protein binding
J	0008270	molecular_function	zinc ion binding
J	0019083	biological_process	viral transcription
J	0030430	cellular_component	host cell cytoplasm
J	0031564	biological_process	transcription antitermination
J	0042025	cellular_component	host cell nucleus
J	0044423	cellular_component	virion component
J	0046782	biological_process	regulation of viral transcription
J	0046872	molecular_function	metal ion binding
J	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
K	0003723	molecular_function	RNA binding
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0008270	molecular_function	zinc ion binding
K	0019083	biological_process	viral transcription
K	0030430	cellular_component	host cell cytoplasm
K	0031564	biological_process	transcription antitermination
K	0042025	cellular_component	host cell nucleus
K	0044423	cellular_component	virion component
K	0046782	biological_process	regulation of viral transcription
K	0046872	molecular_function	metal ion binding
K	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
L	0003723	molecular_function	RNA binding
L	0005198	molecular_function	structural molecule activity
L	0005515	molecular_function	protein binding
L	0008270	molecular_function	zinc ion binding
L	0019083	biological_process	viral transcription
L	0030430	cellular_component	host cell cytoplasm
L	0031564	biological_process	transcription antitermination
L	0042025	cellular_component	host cell nucleus
L	0044423	cellular_component	virion component
L	0046782	biological_process	regulation of viral transcription
L	0046872	molecular_function	metal ion binding
L	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
M	0003723	molecular_function	RNA binding
M	0005198	molecular_function	structural molecule activity
M	0005515	molecular_function	protein binding
M	0008270	molecular_function	zinc ion binding
M	0019083	biological_process	viral transcription
M	0030430	cellular_component	host cell cytoplasm
M	0031564	biological_process	transcription antitermination
M	0042025	cellular_component	host cell nucleus
M	0044423	cellular_component	virion component
M	0046782	biological_process	regulation of viral transcription
M	0046872	molecular_function	metal ion binding
M	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
N	0003723	molecular_function	RNA binding
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0008270	molecular_function	zinc ion binding
N	0019083	biological_process	viral transcription
N	0030430	cellular_component	host cell cytoplasm
N	0031564	biological_process	transcription antitermination
N	0042025	cellular_component	host cell nucleus
N	0044423	cellular_component	virion component
N	0046782	biological_process	regulation of viral transcription
N	0046872	molecular_function	metal ion binding
N	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
O	0003723	molecular_function	RNA binding
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0008270	molecular_function	zinc ion binding
O	0019083	biological_process	viral transcription
O	0030430	cellular_component	host cell cytoplasm
O	0031564	biological_process	transcription antitermination
O	0042025	cellular_component	host cell nucleus
O	0044423	cellular_component	virion component
O	0046782	biological_process	regulation of viral transcription
O	0046872	molecular_function	metal ion binding
O	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade
P	0003723	molecular_function	RNA binding
P	0005198	molecular_function	structural molecule activity
P	0005515	molecular_function	protein binding
P	0008270	molecular_function	zinc ion binding
P	0019083	biological_process	viral transcription
P	0030430	cellular_component	host cell cytoplasm
P	0031564	biological_process	transcription antitermination
P	0042025	cellular_component	host cell nucleus
P	0044423	cellular_component	virion component
P	0046782	biological_process	regulation of viral transcription
P	0046872	molecular_function	metal ion binding
P	0085033	biological_process	symbiont-mediated activation of host NF-kappaB cascade

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 201

Chain	Residue
A	CYS7
A	CYS15
A	CYS21
A	HIS25

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 201

Chain	Residue
B	CYS7
B	CYS15
B	CYS21
B	HIS25

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 201

Chain	Residue
C	CYS15
C	CYS21
C	HIS25
C	CYS7

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 201

Chain	Residue
D	CYS7
D	CYS15
D	CYS21
D	HIS25

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 201

Chain	Residue
E	CYS7
E	CYS15
E	CYS21
E	HIS25

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 201

Chain	Residue
F	CYS7
F	CYS15
F	CYS21
F	HIS25

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN G 201

Chain	Residue
G	CYS7
G	CYS15
G	CYS21
G	HIS25

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN H 201

Chain	Residue
H	CYS7
H	CYS15
H	CYS21
H	HIS25

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 201

Chain	Residue
I	CYS7
I	CYS15
I	CYS21
I	HIS25

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN J 201

Chain	Residue
J	CYS7
J	CYS15
J	CYS21
J	HIS25

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN K 201

Chain	Residue
K	CYS7
K	CYS15
K	CYS21
K	HIS25

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN L 201

Chain	Residue
L	CYS7
L	CYS15
L	CYS21
L	HIS25

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN M 201

Chain	Residue
M	CYS7
M	CYS15
M	CYS21
M	HIS25

---

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN N 201

Chain	Residue
N	CYS7
N	CYS15
N	CYS21
N	HIS25

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN O 201

Chain	Residue
O	CYS7
O	CYS15
O	CYS21
O	HIS25

---

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN P 201

Chain	Residue
P	CYS7
P	CYS15
P	CYS21
P	HIS25

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	216
Details	Zinc finger: {"description":"C3H1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00723","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24434552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32697936","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	272
Details	Region: {"description":"Oligomerization","evidences":[{"source":"PubMed","id":"22675274","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1520
Details	Region: {"description":"Globular core","evidences":[{"source":"PubMed","id":"22675274","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	592
Details	Region: {"description":"Binding to the phosphoprotein","evidences":[{"source":"PubMed","id":"32697936","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	80
Details	Site: {"description":"Involved in RNA-binding","evidences":[{"source":"PubMed","id":"32697936","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	17
Details	Modified residue: {"description":"Phosphoserine; by host","evidences":[{"source":"PubMed","id":"11711610","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---