4C11

Dengue virus RNA dependent RNA polymerase with residues from the NS5 linker region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0005524	molecular_function	ATP binding
A	0039694	biological_process	viral RNA genome replication
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0005524	molecular_function	ATP binding
B	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1889

Chain	Residue
A	HIS712
A	HIS714
A	CYS728
A	CYS847

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1890

Chain	Residue
A	GLU437
A	HIS441
A	CYS446
A	CYS449

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1890

Chain	Residue
B	HIS714
B	CYS728
B	CYS847
B	HIS712

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 1891

Chain	Residue
B	GLU437
B	HIS441
B	CYS446
B	CYS449

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	300
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"Interaction with host KPNA2","evidences":[{"source":"UniProtKB","id":"P12823","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	94
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"source":"UniProtKB","id":"P12823","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17301146","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Site: {"description":"Important for NS5 nuclear subcellular location","evidences":[{"source":"UniProtKB","id":"P12823","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---