Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4C0A

Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0032012	biological_process	regulation of ARF protein signal transduction
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0032012	biological_process	regulation of ARF protein signal transduction
C	0000139	cellular_component	Golgi membrane
C	0000166	molecular_function	nucleotide binding
C	0002090	biological_process	regulation of receptor internalization
C	0003924	molecular_function	GTPase activity
C	0003925	molecular_function	G protein activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006886	biological_process	intracellular protein transport
C	0014069	cellular_component	postsynaptic density
C	0015031	biological_process	protein transport
C	0016192	biological_process	vesicle-mediated transport
C	0016787	molecular_function	hydrolase activity
C	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
C	0042583	cellular_component	chromaffin granule
C	0043005	cellular_component	neuron projection
C	0045202	cellular_component	synapse
C	0060292	biological_process	long-term synaptic depression
C	0097061	biological_process	dendritic spine organization
D	0000139	cellular_component	Golgi membrane
D	0000166	molecular_function	nucleotide binding
D	0002090	biological_process	regulation of receptor internalization
D	0003924	molecular_function	GTPase activity
D	0003925	molecular_function	G protein activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006886	biological_process	intracellular protein transport
D	0014069	cellular_component	postsynaptic density
D	0015031	biological_process	protein transport
D	0016192	biological_process	vesicle-mediated transport
D	0016787	molecular_function	hydrolase activity
D	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
D	0042583	cellular_component	chromaffin granule
D	0043005	cellular_component	neuron projection
D	0045202	cellular_component	synapse
D	0060292	biological_process	long-term synaptic depression
D	0097061	biological_process	dendritic spine organization
E	0005085	molecular_function	guanyl-nucleotide exchange factor activity
E	0032012	biological_process	regulation of ARF protein signal transduction
F	0005085	molecular_function	guanyl-nucleotide exchange factor activity
F	0032012	biological_process	regulation of ARF protein signal transduction
G	0000139	cellular_component	Golgi membrane
G	0000166	molecular_function	nucleotide binding
G	0002090	biological_process	regulation of receptor internalization
G	0003924	molecular_function	GTPase activity
G	0003925	molecular_function	G protein activity
G	0005515	molecular_function	protein binding
G	0005525	molecular_function	GTP binding
G	0005737	cellular_component	cytoplasm
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006886	biological_process	intracellular protein transport
G	0014069	cellular_component	postsynaptic density
G	0015031	biological_process	protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0016787	molecular_function	hydrolase activity
G	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
G	0042583	cellular_component	chromaffin granule
G	0043005	cellular_component	neuron projection
G	0045202	cellular_component	synapse
G	0060292	biological_process	long-term synaptic depression
G	0097061	biological_process	dendritic spine organization
H	0000139	cellular_component	Golgi membrane
H	0000166	molecular_function	nucleotide binding
H	0002090	biological_process	regulation of receptor internalization
H	0003924	molecular_function	GTPase activity
H	0003925	molecular_function	G protein activity
H	0005515	molecular_function	protein binding
H	0005525	molecular_function	GTP binding
H	0005737	cellular_component	cytoplasm
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006886	biological_process	intracellular protein transport
H	0014069	cellular_component	postsynaptic density
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0016787	molecular_function	hydrolase activity
H	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
H	0042583	cellular_component	chromaffin granule
H	0043005	cellular_component	neuron projection
H	0045202	cellular_component	synapse
H	0060292	biological_process	long-term synaptic depression
H	0097061	biological_process	dendritic spine organization

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G3D C 401

Chain	Residue
C	LEU25
C	ASP129
C	CYS159
C	ALA160
C	THR161
F	LYS498
C	ALA27
C	ALA28
C	GLY29
C	LYS30
C	THR31
C	THR32
C	ASN126
C	LYS127

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G3D D 401

Chain	Residue
D	ALA27
D	ALA28
D	GLY29
D	LYS30
D	THR31
D	THR32
D	ASN126
D	LYS127
D	ASP129
D	LEU130
D	CYS159
D	ALA160
D	THR161
E	LYS498

site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G3D G 401

Chain	Residue
B	LYS498
G	LEU25
G	ALA27
G	ALA28
G	GLY29
G	LYS30
G	THR31
G	THR32
G	ASN126
G	LYS127
G	ASP129
G	CYS159
G	ALA160
G	THR161

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE G3D H 401

Chain	Residue
A	LYS498
H	LEU25
H	ALA27
H	ALA28
H	GLY29
H	LYS30
H	THR31
H	THR32
H	ASN126
H	LYS127
H	ASP129
H	CYS159
H	ALA160
H	THR161

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	368
Details	Domain: {"description":"PH"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	93
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	193
Details	Domain: {"description":"SEC7","evidences":[{"source":"PROSITE-ProRule","id":"PRU00189","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14654833","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24058294","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1R8Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1R8S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1S9D","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4C0A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)