4BY9

The structure of the Box CD enzyme reveals regulation of rRNA methylation

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005515	molecular_function	protein binding
C	0030515	molecular_function	snoRNA binding
C	0031428	cellular_component	box C/D methylation guide snoRNP complex
C	0032040	cellular_component	small-subunit processome
D	0001682	biological_process	tRNA 5'-leader removal
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0004526	molecular_function	ribonuclease P activity
D	0005737	cellular_component	cytoplasm
D	0005840	cellular_component	ribosome
D	0006364	biological_process	rRNA processing
D	0006412	biological_process	translation
D	0008033	biological_process	tRNA processing
D	0019843	molecular_function	rRNA binding
D	0042254	biological_process	ribosome biogenesis
D	1990904	cellular_component	ribonucleoprotein complex
E	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
E	0003723	molecular_function	RNA binding
E	0005515	molecular_function	protein binding
E	0006338	biological_process	chromatin remodeling
E	0006364	biological_process	rRNA processing
E	0008033	biological_process	tRNA processing
E	0008168	molecular_function	methyltransferase activity
E	0008649	molecular_function	rRNA methyltransferase activity
E	0031167	biological_process	rRNA methylation
E	0032259	biological_process	methylation
E	1990259	molecular_function	histone H2AQ104 methyltransferase activity
F	0005515	molecular_function	protein binding
F	0030515	molecular_function	snoRNA binding
F	0031428	cellular_component	box C/D methylation guide snoRNP complex
F	0032040	cellular_component	small-subunit processome
G	0001682	biological_process	tRNA 5'-leader removal
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0004526	molecular_function	ribonuclease P activity
G	0005737	cellular_component	cytoplasm
G	0005840	cellular_component	ribosome
G	0006364	biological_process	rRNA processing
G	0006412	biological_process	translation
G	0008033	biological_process	tRNA processing
G	0019843	molecular_function	rRNA binding
G	0042254	biological_process	ribosome biogenesis
G	1990904	cellular_component	ribonucleoprotein complex
H	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
H	0003723	molecular_function	RNA binding
H	0005515	molecular_function	protein binding
H	0006338	biological_process	chromatin remodeling
H	0006364	biological_process	rRNA processing
H	0008033	biological_process	tRNA processing
H	0008168	molecular_function	methyltransferase activity
H	0008649	molecular_function	rRNA methyltransferase activity
H	0031167	biological_process	rRNA methylation
H	0032259	biological_process	methylation
H	1990259	molecular_function	histone H2AQ104 methyltransferase activity
I	0005515	molecular_function	protein binding
I	0030515	molecular_function	snoRNA binding
I	0031428	cellular_component	box C/D methylation guide snoRNP complex
I	0032040	cellular_component	small-subunit processome
J	0001682	biological_process	tRNA 5'-leader removal
J	0003723	molecular_function	RNA binding
J	0003735	molecular_function	structural constituent of ribosome
J	0004526	molecular_function	ribonuclease P activity
J	0005737	cellular_component	cytoplasm
J	0005840	cellular_component	ribosome
J	0006364	biological_process	rRNA processing
J	0006412	biological_process	translation
J	0008033	biological_process	tRNA processing
J	0019843	molecular_function	rRNA binding
J	0042254	biological_process	ribosome biogenesis
J	1990904	cellular_component	ribonucleoprotein complex
K	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
K	0003723	molecular_function	RNA binding
K	0005515	molecular_function	protein binding
K	0006338	biological_process	chromatin remodeling
K	0006364	biological_process	rRNA processing
K	0008033	biological_process	tRNA processing
K	0008168	molecular_function	methyltransferase activity
K	0008649	molecular_function	rRNA methyltransferase activity
K	0031167	biological_process	rRNA methylation
K	0032259	biological_process	methylation
K	1990259	molecular_function	histone H2AQ104 methyltransferase activity
L	0005515	molecular_function	protein binding
L	0030515	molecular_function	snoRNA binding
L	0031428	cellular_component	box C/D methylation guide snoRNP complex
L	0032040	cellular_component	small-subunit processome
M	0001682	biological_process	tRNA 5'-leader removal
M	0003723	molecular_function	RNA binding
M	0003735	molecular_function	structural constituent of ribosome
M	0004526	molecular_function	ribonuclease P activity
M	0005737	cellular_component	cytoplasm
M	0005840	cellular_component	ribosome
M	0006364	biological_process	rRNA processing
M	0006412	biological_process	translation
M	0008033	biological_process	tRNA processing
M	0019843	molecular_function	rRNA binding
M	0042254	biological_process	ribosome biogenesis
M	1990904	cellular_component	ribonucleoprotein complex
N	0000494	biological_process	box C/D sno(s)RNA 3'-end processing
N	0003723	molecular_function	RNA binding
N	0005515	molecular_function	protein binding
N	0006338	biological_process	chromatin remodeling
N	0006364	biological_process	rRNA processing
N	0008033	biological_process	tRNA processing
N	0008168	molecular_function	methyltransferase activity
N	0008649	molecular_function	rRNA methyltransferase activity
N	0031167	biological_process	rRNA methylation
N	0032259	biological_process	methylation
N	1990259	molecular_function	histone H2AQ104 methyltransferase activity

Functional Information from PROSITE/UniProt

site_id	PS00566
Number of Residues	15
Details	FIBRILLARIN Fibrillarin signature. GKIYGIEFSpRvlRE

Chain	Residue	Details
E	GLY99-GLU113

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site_id	PS01082
Number of Residues	18
Details	RIBOSOMAL_L7AE Ribosomal protein L7Ae signature. CeekeIPYiyVpSKkeLG

Chain	Residue	Details
D	CYS68-GLY85

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00351

Chain	Residue	Details
E	THR86
H	THR86
K	THR86
N	THR86

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
E	GLU105
N	GLU105
N	ASP130
N	ASP150
E	ASP130
E	ASP150
H	GLU105
H	ASP130
H	ASP150
K	GLU105
K	ASP130
K	ASP150

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